PMID: 8587143Dec 1, 1995Paper

Repetitive DNA sequences located in the central region of the human mdr1 (multidrug resistance) gene may account for a gene fusion event during its evolution

Journal of Molecular Evolution
M PaulyM Dicato

Abstract

The mdr1 gene, first member of the human multidrug-resistance gene family, is a major gene involved in cellular resistance to several drugs used in anticancer chemotherapy. Its product, the drug-excreting P-glycoprotein, shows a bipartite structure formed by two similar adjacent halves. According to one hypothesis, the fusion of two related ancestral genes during evolution could have resulted in this structure. The DNA sequence analysis of the introns located in the region connecting the two halves of the human mdr1 gene revealed a highly conserved poly(CA).poly (TG) sequence in intron 15 and repeated sequences of the Alu family in introns 14 and 17. These repeated sequences most likely represent "molecular fossils" of ancient DNA elements which were involved in such a recombination event.

Citations

Dec 14, 2007·Systematic Biology·John P Huelsenbeck, Marc A Suchard
Oct 15, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ziheng Yang
Jan 10, 2009·PLoS Computational Biology·Kemal SonmezLawrence Toll
May 10, 2019·Bioinformatics·Alexey M KozlovAlexandros Stamatakis
Jan 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Hamutal ArbelJames B Brown
Oct 15, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ofir CohenTal Pupko
Dec 6, 2016·Life·Derek Caetano-Anollés, Gustavo Caetano-Anollés
Aug 23, 2019·Molecular Biology and Evolution·Diego DarribaTomas Flouri
Oct 8, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David López-EscardóIñaki Ruiz-Trillo
Mar 1, 2019·Systematic Biology·Sandra Álvarez-CarreteroMario Dos Reis
Nov 7, 2007·PLoS Computational Biology·Chen-Hsiang Yeang, David Haussler
Mar 17, 2020·Molecular Biology and Evolution·Noah DuklerAdam Siepel

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