Repetitive enhancement of serum BDNF subsequent to continuation ECT

Acta Psychiatrica Scandinavica
T VanicekR Frey

Abstract

Continuation electroconvulsive therapy (c-ECT) is highly effective for the prevention of depressive symptom relapse. There is a lack of understanding, about how c-ECT works in humans, particularly with regard to its effects on brain derived neurotrophic factor (BDNF) concentrations. Here, we aimed to close a gap in the literature by evaluating BDNF levels in patients receiving c-ECT. We included 13 patients with either unipolar or bipolar depression (mean age ± SD: 55.5 ± 17.1; f/m: 10/3; unipolar/bipolar: 10/3) who received between one and four c-ECT (average per patient: 2.8). Serum BDNF (sBDNF) levels were assessed before and after each c-ECT sessions. Clinical assessments were also administered both before and after treatment. Our analysis revealed a significant increase in sBDNF after each treatment (c-ECT 1-3: P < 0.001, c-ECT 4: P = 0.018). The application of multiple c-ECT treatments was not, however, associated with further sBDNF enhancements. Psychometric scores were not significantly altered following c-ECT. An increase in sBDNF concentrations subsequent to c-ECT parallel data from the animal literature, which has linked regularly applied electrical stimulation to neuroplastic processes. This finding suggests a relat...Continue Reading

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Citations

Dec 11, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Matthias BesseDavid Zilles
Oct 23, 2019·Chemical Senses·Georg S KranzRupert Lanzenberger
Jun 14, 2021·Brain Stimulation·Gregor GryglewskiPia Baldinger-Melich

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Methods Mentioned

BETA
enzyme‐linked immunosorbent assay

Software Mentioned

SPSS Statistics

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