Repetitive firing and oscillatory activity of pyramidal-like bursting neurons in the rat subiculum

Experimental Brain Research
D MattiaM Avoli

Abstract

Electrophysiological characterization of neurons within the rat subiculum was carried out with intracellular recordings in an in vitro slice preparation. Subicular neurons responded to threshold pulses of depolarizing current delivered at a resting membrane potential (RMP) of 45.7+/-5.8 mV (mean+/-SD, n=85) with an initial burst of three to five fast action potentials that rode on a depolarizing envelope and was terminated by an afterhyperpolarization (burst AHP) (duration 113+/-35 ms; peak amplitude 2.7+/-0.6 mV, n=10). Tonic firing replaced the bursting mode at membrane potential less negative than -55 mV. Suprathreshold depolarizing pulses evoked at RMP both an initial burst and successive tonic firing. Intracellular staining with biocytin showed morphological features typical of pyramidal cells (n=8). The relationship between frequency of repetitive firing and injected current (f-I) revealed that the burst firing frequency (250-300 Hz) was only slightly influenced by the amount of injected current. By contrast, the f-I curve of the tonic firing phase depended upon current intensity: it displayed an initial segment that increased at first linearly and then turned into a plateau for both the early and the late inter-spike int...Continue Reading

Citations

Mar 10, 2001·Progress in Neurobiology·S M O'MaraJ Gigg
Aug 10, 2002·The European Journal of Neuroscience·Jörg WellmerYoel Yaari
Feb 9, 2005·The Journal of Comparative Neurology·Andreas KnoppJoachim Behr
May 19, 2004·The European Journal of Neuroscience·Martin VreugdenhilWytse J Wadman
Jun 16, 2004·Journal of Neuroscience Methods·Robert T MatthewsDanny G Winder
Jun 24, 2017·The European Journal of Neuroscience·Maxime LévesqueMassimo Avoli
Feb 10, 2006·Journal of Neurophysiology·P AracriS Franceschetti
Nov 9, 2000·Journal of Neurophysiology·N P StaffN Spruston
Mar 5, 2021·Reviews in the Neurosciences·Maxime Lévesque, Massimo Avoli

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