Repetitive transcranial magnetic stimulation for post-stroke depression: a randomised trial with neurophysiological insight.

Journal of Neurology
Brenton HordacreSusan Hillier

Abstract

Despite high incidence of depression after stroke, few trials have investigated the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS). Here, we aimed to evaluate clinical benefit of delivering a higher dose of rTMS compared to previous stroke trials. Secondary aims were to document adverse effects and investigate the role of functional connectivity as a potential mechanism of clinical response to rTMS treatment. Eleven chronic stroke survivors were recruited to a double-blind, Sham-controlled, randomised trial to investigate 10 sessions of high-frequency rTMS for depression. Clinical assessments were obtained at baseline, after treatment and a 1-month follow-up. Adverse events were documented at completion of the treatment. Resting electroencephalography recordings were performed at baseline and after treatment to estimate functional connectivity. There were no differences in baseline characteristics between groups (all p ≥ 0.42). Beck Depression Inventory scores decreased for the Active rTMS group from baseline to 1-month follow-up (p = 0.04), but did not change for the Sham group at post-treatment or follow-up (p ≥ 0.17). Stronger theta frequency functional connectivity between the left frontal corte...Continue Reading

References

Aug 1, 1994·Brain : a Journal of Neurology·A Pascual-LeoneM Hallett
May 29, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·W MuellbacherM Hallett
Nov 14, 2000·Archives of Neurology·C F BladinJ W Norris
Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Aug 17, 2002·Biological Psychiatry·Ellen M Whyte, Benoit H Mulsant
May 24, 2003·Brain : a Journal of Neurology·N S WardR S J Frackowiak
Aug 26, 2003·Brain : a Journal of Neurology·N S WardR S J Frackowiak
May 10, 2005·Stroke; a Journal of Cerebral Circulation·Maree L HackettCraig S Anderson
May 11, 2005·Neurorehabilitation and Neural Repair·S K SchiemanckA J H Prevo
Jan 3, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Katsuyuki MachiiAlvaro Pascual-Leone
Sep 15, 2007·Brain : a Journal of Neurology·Lara MenziesEd Bullmore
May 24, 2008·Neuroscience and Biobehavioral Reviews·Paul Sauseng, Wolfgang Klimesch
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Stefano Paolucci
Jun 15, 2010·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Robert G Robinson, Gianfranco Spalletta
Aug 28, 2010·Disability and Rehabilitation·Fiona Jones, Afsane Riazi
Dec 17, 2010·Expert Review of Medical Devices·Paul B Fitzgerald, Zafiris J Daskalakis
Jan 14, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Simone RossiAlvaro Pascual-Leone
Feb 16, 2011·The International Journal of Neuropsychopharmacology·Andre Russowsky BrunoniFelipe Fregni
Aug 4, 2011·BMJ : British Medical Journal·Carol CouplandJulia Hippisley-Cox
Mar 19, 2014·Biological Psychiatry·Conor ListonMarc J Dubin
Aug 15, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Maree L Hackett, Kristen Pickles
Dec 20, 2016·The European Journal of Neuroscience·Brenton HordacreMichael C Ridding
May 22, 2020·Neurorehabilitation and Neural Repair·Brenton HordacreSusan Hillier

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