Repetitive transcranial magnetic stimulation of the primary motor cortex in the treatment of motor signs in Parkinson's disease: A quantitative review of the literature

Movement Disorders : Official Journal of the Movement Disorder Society
Anosha ZanjaniRobert Chen

Abstract

Parkinson's disease (PD) is a progressive disorder characterized by the emergence of motor deficits. In light of the voluminous and conflicting findings in the literature, the aim of the present quantitative review was to examine the effects of repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex (M1) in the treatment of motor signs in PD. Studies meeting inclusion criteria were analyzed using meta-analytic techniques and the Unified Parkinson's Disease Rating Scale (UPDRS) sections II and III were used as outcome measures. In order to determine the treatment effects of rTMS, the UPDRS II and III scores obtained at baseline, same day, to 1 day post rTMS treatment (short-term follow-up) and 1-month post stimulation (long-term follow-up) were compared between the active and sham rTMS groups. Additionally, the placebo effect was evaluated as the changes in UPDRS III scores in the sham rTMS groups. A placebo effect was not demonstrated, because sham rTMS did not improve motor signs as measured by UPDRS III. Compared with sham rTMS, active rTMS targeting the M1 significantly improved UPDRS III scores at the short-term follow-up (Cohen's d of 0.27, UPDRS III score improvement of 3.8 points). When the...Continue Reading

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Citations

Aug 16, 2016·Journal of Neural Transmission·Song LiWeidong Le
Jan 27, 2018·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Oren S CohenSharon Hassin-Baer
Jun 11, 2019·Clinical Pharmacology and Therapeutics·Kai-Hsiang Stanley Chen, Robert Chen
Aug 18, 2016·JBI Database of Systematic Reviews and Implementation Reports·Erica TilleyMicah D J Peters
Jul 1, 2017·Frontiers in Aging Neuroscience·Assenza GiovanniVincenzo Di Lazzaro
Apr 30, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Anna LatorreJohn C Rothwell
Mar 22, 2020·International Journal of Biometeorology·Javier RianchoPablo Fdez-Arroyabe
Jan 7, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurUlf Ziemann

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