Repetitive transcranial magnetic stimulation plus standardized suggestion of benefit for functional movement disorders: an open label case series

Parkinsonism & Related Disorders
B B ShahA E Lang

Abstract

We studied suggestion of benefit combined with motor cortex and premotor cortex repetitive transcranial magnetic stimulation (rTMS) in chronic (>2 years) FMDs. Patients were identified from our patient records who had clinically definite FMDs and had undergone neuropsychiatric evaluation. Those with chronic FMDs were offered open-label rTMS over the dominant motor cortex. If they failed to improve they received dominant premotor cortex rTMS. The primary outcome was change from baseline to post-rTMS in quality of life measured by the World Health Organization Quality of Life Brief (WHOQOL-BREF) scale. Secondary outcomes were subject and investigator global impression of change (GIC), blinded Rush psychogenic movements rating scale, Barbers suggestibility scale, baseline expectation of benefit scale, and adverse effects. Six subjects were enrolled. For the primary outcome, there was significant improvement in the physical domain scores but significant reduction in psychological domain scores after premotor cortex rTMS compared to baseline and after motor cortex rTMS. There was no significant change between baseline and motor cortex rTMS or in any other domain after premotor cortex rTMS. Secondary outcome measures showed no meanin...Continue Reading

References

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Oct 31, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Behzad ElahiRobert Chen
Oct 17, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Simone RossiUNKNOWN Safety of TMS Consensus Group
Jan 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Michel C F Shamy
Mar 12, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Mark J EdwardsCarla Cordivari
Jan 11, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Thomas A PollakAnthony S David
Feb 7, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Béatrice GarcinBertrand Degos

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Citations

Nov 20, 2015·Lancet Neurology·Diego KaskiJon Stone
Jun 17, 2016·Current Opinion in Neurology·Tiago Teodoro, Mark J Edwards
Jun 11, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Simon TaibMarion Simonetta-Moreau
May 3, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Benedetta DemartiniOrsola Gambini

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