Replacement Bisphenols Adversely Affect Mouse Gametogenesis with Consequences for Subsequent Generations

Current Biology : CB
Tegan S HoranPatricia A Hunt

Abstract

20 years ago, accidental bisphenol A (BPA) exposure caused a sudden increase in chromosomally abnormal eggs from our control mice [1]. Subsequent rodent studies demonstrated developmental effects of exposure with repercussions on adult health and fertility (e.g., [2-9]; reviewed in [10-17]). Studies in monkeys, humans, fish, and worms suggest BPA effects extend across species (e.g., [18-30]; reviewed in [31-33]). Widespread use has resulted in ubiquitous environmental contamination and human BPA exposure. Consumer concern resulted in "BPA-free" products produced using structurally similar bisphenols that are now detectable environmental and human contaminants (e.g., [34-41]). We report here studies initiated by meiotic changes mirroring our previous BPA experience and implicating exposure to BPS (a common BPA replacement) from damaged polysulfone cages. Like with BPA [1, 2, 5], our data show that exposure to common replacement bisphenols induces germline effects in both sexes that may affect multiple generations. These findings add to growing evidence of the biological risks posed by this class of chemicals. Rapid production of structural variants of BPA and other EDCs circumvents efforts to eliminate dangerous chemicals, exace...Continue Reading

Citations

May 15, 2019·Obstetrics and Gynecology·Elizabeth S RubinSusan Kellogg Spadt
May 28, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mingxin ShiKanako Hayashi
Oct 20, 2018·Nature Reviews. Endocrinology·Genoa R Warner, Jodi A Flaws
May 29, 2019·Obstetrics and Gynecology·Elizabeth S RubinSusan Kellogg Spadt
Jun 26, 2020·Frontiers in Endocrinology·Luca De ToniCarlo Foresta
Aug 1, 2019·Current Neuropharmacology·Antonietta SantoroRosaria Meccariello
Sep 19, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mingxin ShiKanako Hayashi
Sep 24, 2020·Microorganisms·Stephanie Serena SchäpeNico Jehmlich
Mar 6, 2019·International Journal of Environmental Research and Public Health·Shiqiu ZhangJinpeng Liu
Feb 8, 2020·Nature Reviews. Disease Primers·Stylianos E AntonarakisRoger H Reeves
Jan 31, 2021·Chemosphere·Hunter B RogersTeresa K Woodruff
Jun 3, 2021·Journal of Biochemical and Molecular Toxicology·S Shehna MahimC Aruna Devi
May 19, 2021·Journal of Hazardous Materials·Md Saidur RahmanMyung-Geol Pang
Nov 19, 2021·Genetics·Angela Belmonte TebarElena de la Casa-Esperon

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