Replacement of major surgical blood loss by hypo-oncotic or conventional plasma substitutes

Acta Anaesthesiologica Scandinavica
S HiippalaA Mäkeläinen

Abstract

The purpose of the study was to examine the effects of hypooncotic 4% hydroxyethyl starch 120/0.7, 3% dextran 70, 5% albumin and hyperoncotic 6% hydroxyethyl starch 120/0.7 on the perioperative colloid osmotic pressure (COP), albumin and protein concentrations and fluid balance. The plasma substitutes were used with red cell concentrates to replace blood loss with equal volume in sixty major abdominal or urological surgeries. A special effort was made to keep replacements and losses at even volumes constantly and to avoid fluctuation of blood volume. The blood specimen were obtained before induction, after each 20% blood loss, at the end of the recovery room phase and on the three following postoperative mornings. There were significant differences in the peroperative and immediate postoperative COPs. However, these differences had vanished by the first postoperative morning. COP was preserved above 16 mmHg in all groups throughout the study. The identical peroperative albumin and protein concentrations of the synthetic colloid groups suggests that their volume effect was the same, regardless of the varying COP. During the observation period there were no significant differences among the groups concerning the diuresis and the ...Continue Reading

References

Jan 1, 1990·International Anesthesiology Clinics·G P Gravlee
Sep 1, 1985·Critical Care Medicine·I DawidsonJ Reisch
May 1, 1988·Journal of Clinical Pharmacology·J L FalkM H Weil
Feb 1, 1987·World Journal of Surgery·C F HögmanL Thorén
Jan 1, 1967·Scandinavian Journal of Clinical and Laboratory Investigation·H J Ladegaard-Pedersen
Jul 1, 1984·Journal of Clinical Pharmacology·K KorttilaM A Mattila
Mar 1, 1983·Critical Care Medicine·C R Shippy, W C Shoemaker

❮ Previous
Next ❯

Citations

Oct 19, 2010·Journal of Anesthesia·Tomi T NiemiMichiaki Yamakage
Nov 11, 1998·Acta Anaesthesiologica Scandinavica·T T Niemi, A H Kuitunen
Aug 15, 1998·Vox Sanguinis·S Hiippala
Nov 26, 2004·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society
Oct 30, 2010·Critical Care : the Official Journal of the Critical Care Forum·Christian J WiedermannMichael Joannidis
Aug 6, 2009·Best Practice & Research. Clinical Anaesthesiology·Christian ErtmerMartin Westphal
Mar 26, 2003·Anesthesia and Analgesia·Kai SingbartlHugo Van Aken
Aug 1, 1996·Anesthesia and Analgesia·R J Traylor, R G Pearl
Mar 1, 1998·Journal of Anesthesia·Kiyoshi HoribaHiroshi Noguchi
Mar 17, 2005·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Masuhiko Takaori

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.