Replacement of recipient stromal/mesenchymal cells after bone marrow transplantation using bone fragments and cultured osteoblast-like cells

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Richard A CahillRobert A Good

Abstract

Abstract We present our experience on treatment of three children with potentially fatal diseases using a unique protocol for non-myeloablative bone marrow transplantation. The protocol was designed to promote engraftment of bone marrow stromal/mesenchymal cells (SC/MSCs) based on the knowledge from preclinical models over the last three decades. Accordingly, our protocol is the first to test the use of bone fragments as an ideal vehicle to transplant such cells residing in the bone core. Because of the paucity of knowledge for optimum transplantation of SC/MSCs in humans, we used a multifaceted approach and implanted bone fragments both intraperitoneally and directly into bone on day 0 of BMT. We also infused cultured donor osteoblast-like cells intravenously post-BMT. We were able to achieve high levels of stroma cell engraftment as defined by molecular analyses of bone biopsy specimens.

References

Jun 1, 1977·Journal of Cellular Physiology·T M DexterL G Lajtha
Nov 1, 1990·Journal of Clinical Pathology·S A Dilly, C J Jagger
Sep 1, 1985·Calcified Tissue International·P G Robey, J D Termine
Mar 1, 1986·Calcified Tissue International·C G BellowsM E Antosz
May 1, 1987·Cell and Tissue Kinetics·A J FriedensteinU V Gerasimov
Feb 1, 1995·The Journal of Clinical Investigation·M W LongK G Mann
Sep 1, 1995·Stem Cells·C E Müller-Sieburg, E Deryugina
Sep 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S A KuznetsovP G Robey
Feb 25, 1998·Stem Cells·R S Taichman, S G Emerson
Feb 23, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·X D ChenM C Horowitz
May 25, 1999·Bone Marrow Transplantation·C del CañizoJ F San Miguel
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·Z HouG S Stein
Jan 5, 2000·The Journal of Clinical Investigation·D Y JoM A Moore
Apr 27, 2000·Experimental Hematology·J M NelissenC G Figdor
Jun 1, 2000·Bone Marrow Transplantation·C Peters, W Krivit
Sep 16, 2000·Experimental Hematology·R J Deans, A B Moseley
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Won Young LeeChoon Choo Kim

❮ Previous
Next ❯

Citations

Feb 26, 2010·Der Orthopäde·M JägerR Krauspe
May 29, 2008·Immunologic Research·Nagwa S El-BadriRobert A Good
Sep 9, 2005·International Journal of Hematology·Jing WangDao-Pei Lu
Aug 3, 2011·Orthopedic Reviews·Marcus JägerRüdiger Krauspe
Jun 14, 2013·Journal of Nucleic Acids·Nagwa El-Badri, Mohamed A Ghoneim
Oct 21, 2005·Leukemia & Lymphoma·Kevin C KempCraig Donaldson
Nov 10, 2010·Expert Opinion on Biological Therapy·Timothy J MyersAnna Spagnoli
Apr 30, 2010·Differentiation; Research in Biological Diversity·Jun LiLanjuan Li
Feb 5, 2009·Cytotherapy·Reena JethvaEdwin M Horwitz
Oct 24, 2007·Journal of Internal Medicine·K Le Blanc, O Ringdén
Jan 9, 2013·Journal of the Neurological Sciences·Jeffrey A Cohen
Jul 14, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jing-Jing LiuHong Shan
May 24, 2007·The Journal of Clinical Endocrinology and Metabolism·Richard A CahillMichael P Whyte
Oct 23, 2019·International Journal of Molecular Sciences·Masahiro YamadaHiroshi Egusa
Feb 14, 2017·Stem Cells Translational Medicine·Christopher R Nitkin, Tracey L Bonfield
Jun 3, 2021·International Journal of Molecular Sciences·Elise AasebøØystein Bruserud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.