Abstract
Active metabolism of peripheral blood mononuclear cells (PBMC) could suggest their suitability for metabolomics studies. This study examined whether reductions in PBMCs and plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) activities induced by dietary intervention affected the overall metabolic profiles of PBMC and plasma. Eighty nonobese subjects aged 40-70 years (18.5 ≤ BMI < 30 kg/m(2)) with prediabetes or newly-diagnosed type-2 diabetes were assigned to consume either the usual refined-rice diet (control group, n = 40) or to replace refined rice with whole grains and legumes as carbohydrates (whole-grain group, n = 40) for three meals per day during the 12-week intervention. Fasting PBMC and plasma metabolomes were profiled using UPLC-LTQ-Orbitrap mass spectrometry. After 12 weeks, changes in fasting glucose, HbA1c, HOMA-IR, MDA, ox-LDL, LDL particle size, plasma Lp-PLA2 activity, and PBMC enzyme activity in the whole-grain group were significantly different from those in the control group before and after adjusting for baseline levels. The PBMC levels of L-leucine, oleamide, lysoPC (16:0), and lysoPC (18:0) in the whole-grain group showed greater reductions compared with those of the control group. Changes in plasm...Continue Reading
References
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Feb 15, 1996·European Journal of Biochemistry·C DentanE Ninio
Jul 1, 1997·Diabetes Care
Aug 1, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·K G Alberti, P Z Zimmet
Sep 30, 2000·The American Journal of Clinical Nutrition·S LiuJ E Buring
Feb 16, 2002·European Heart Journal·T SkoogA Hamsten
Jan 29, 2005·Diabetes Care·Ann Marie McNeillGerardo Heiss
Oct 22, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Eric H YangAmir Lerman
Apr 8, 2006·Journal of Biotechnology·Martin KussmannMichael Affolter
Jun 13, 2006·Atherosclerosis·Yi ShiRobert L Wilensky
Apr 25, 2007·Free Radical Research·Ana B CrujeirasJ Alfredo Martínez
Jun 9, 2007·The American Journal of Clinical Nutrition·David R JacobsRune Blomhoff
Jan 29, 2008·Current Medicinal Chemistry·Takayuki MatsumotoKatsuo Kamata
Aug 9, 2008·Omics : a Journal of Integrative Biology·Ana B CrujeirasJ Alfredo Martínez
Sep 23, 2008·Nature Medicine·Robert L WilenskyColin H Macphee
Jan 10, 2009·Diabetes Care·Hye Kyung ChungJong Ho Lee
Oct 3, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Dieuwke De KeyzerEwa Ninio
Nov 17, 2009·Cardiovascular Research·Wen-Yi WangYi-ping Wang
Jan 29, 2010·The American Journal of Clinical Nutrition·Ida J HatoumEric B Rimm
Jun 18, 2011·Omics : a Journal of Integrative Biology·Hans-Richard BrattbakkBerit Johansen
Oct 1, 2011·Clinical Endocrinology·Chang Young HaJong Ho Lee
Feb 24, 2012·PloS One·Jean Kyung PaikJong Ho Lee
Mar 9, 2012·The Journal of Clinical Endocrinology and Metabolism·T L NelsonK J Mukamal
May 18, 2013·Nutrition Journal·Damien P Belobrajdic, Anthony R Bird
Jul 12, 2013·Oxidative Medicine and Cellular Longevity·Alexandra Muñoz, Max Costa
Dec 21, 2013·PloS One·Anna Fratta PasiniUlisse Garbin
Jun 7, 2014·Journal of Lipid Research·Minjoo KimJong Ho Lee
Citations
May 20, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Minjoo KimJong Ho Lee
Aug 23, 2018·Clinical Genetics·Minkyung KimJong Ho Lee
Dec 7, 2017·PloS One·Minjoo KimJong Ho Lee
Oct 3, 2020·Nutrients·Jun Wern YauAmutha Ramadas
Dec 7, 2017·Lipids in Health and Disease·Minjoo KimJong Ho Lee
Feb 12, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Minjoo KimJong Ho Lee
Feb 2, 2019·Nutrients·Sebastià GalmésFrancisca Serra
Oct 17, 2018·Lipids in Health and Disease·Miso KangJong Ho Lee
Mar 4, 2018·Cancer Prevention Research·Sun Ha JeeJong Ho Lee
Sep 18, 2020·Journal of Diabetes and Its Complications·Minjueng MaMinjoo Kim
Oct 16, 2021·Nutrition Reviews·Carolyn J EnglishDianne P Reidlinger