Replanning Criteria and Timing Definition for Parotid Protection-Based Adaptive Radiation Therapy in Nasopharyngeal Carcinoma

BioMed Research International
Weirong YaoLin Ma

Abstract

The goal of this study was to evaluate real-time volumetric and dosimetric changes of the parotid gland so as to determine replanning criteria and timing for parotid protection-based adaptive radiation therapy in nasopharyngeal carcinoma. Fifty NPC patients were treated with helical tomotherapy; volumetric and dosimetric (D mean, V 1, and D 50) changes of the parotid gland at the 1st, 6th, 11th, 16th, 21st, 26th, 31st, and 33rd fractions were evaluated. The clinical parameters affecting these changes were studied by analyses of variance methods for repeated measures. Factors influencing the actual parotid dose were analyzed by a multivariate logistic regression model. The cut-off values predicting parotid overdose were developed from receiver operating characteristic curves and judged by combining them with a diagnostic test consistency check. The median absolute value and percentage of parotid volume reduction were 19.51 cm(3) and 35%, respectively. The interweekly parotid volume varied significantly (p < 0.05). The parotid D mean, V 1, and D 50 increased by 22.13%, 39.42%, and 48.45%, respectively. The actual parotid dose increased by an average of 11.38% at the end of radiation therapy. Initial parotid volume, initial paroti...Continue Reading

References

May 30, 2003·Medical Physics·Joseph O DeasyVanessa H Clark
Sep 9, 2005·Physics in Medicine and Biology·K M LangenG H Olivera
Nov 1, 2005·International Journal of Radiation Oncology, Biology, Physics·Eric K HansenPing Xia
Apr 22, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter M L TeoAnthony T C Chan
Dec 5, 2006·International Journal of Radiation Oncology, Biology, Physics·Yun LiAvraham Eisbruch
Feb 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Chunhui HanJeffrey Y C Wong
Jul 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy LeeK Kian Ang
Oct 27, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tara A van de WaterJohannes A Langendijk
Feb 2, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sara BroggiRiccardo Calandrino
Mar 27, 2010·International Journal of Radiation Oncology, Biology, Physics·Shreerang A BhideChristopher M Nutting
Jul 14, 2010·International Journal of Radiation Oncology, Biology, Physics·Peter H AhnMadhur K Garg
Nov 3, 2010·International Journal of Radiation Oncology, Biology, Physics·Sheng-Fa SuTai-Xiang Lu
Nov 3, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Liang ZhaoShixiu Wu
Dec 6, 2011·International Journal of Radiation Oncology, Biology, Physics·David L SchwartzLei Dong
Dec 27, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·L CapelleR Scrimger
Feb 2, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M N DumaH Geinitz
May 11, 2012·The British Journal of Radiology·A FiorentinoV Fusco
Sep 22, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gang PengGang Wu
Jan 23, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tamaki NishiMasahiko Okumura
Feb 2, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·David L SchwartzLei Dong
Feb 28, 2013·Physics in Medicine and Biology·Xuejun GuSteve B Jiang
Aug 31, 2013·Journal of Radiation Research·Winky Wing Ki FungPeter Man Lung Teo
Sep 17, 2013·International Journal of Radiation Oncology, Biology, Physics·Klaudia U HunterAvraham Eisbruch
Oct 22, 2013·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Chuanben ChenJianji Pan
Jul 5, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Elizabeth BrownSandro Porceddu

❮ Previous
Next ❯

Software Mentioned

HT
SPSS
Planned Adaptive
TomoTherapy Hi - Art

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.