Replay of cortical spiking sequences during human memory retrieval.

Science
Alex P VazKareem A Zaghloul

Abstract

Episodic memory retrieval is thought to rely on the replay of past experiences, yet it remains unknown how human single-unit activity is temporally organized during episodic memory encoding and retrieval. We found that ripple oscillations in the human cortex reflect underlying bursts of single-unit spiking activity that are organized into memory-specific sequences. Spiking sequences occurred repeatedly during memory formation and were replayed during successful memory retrieval, and this replay was associated with ripples in the medial temporal lobe. Together, these data demonstrate that human episodic memory is encoded by specific sequences of neural activity and that memory recall involves reinstating this temporal order of activity.

References

Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y NayaY Miyashita
Dec 24, 2002·Neuron·Albert K Lee, Matthew A Wilson
Dec 19, 2006·Nature Neuroscience·Daoyun Ji, Matthew A Wilson
Jan 6, 2007·Cerebral Cortex·Jeffrey D Johnson, Michael D Rugg
May 23, 2007·Journal of Neuroscience Methods·Eric Maris, Robert Oostenveld
Sep 11, 2007·Nature Neuroscience·Kamran Diba, György Buzsáki
May 27, 2008·Brain : a Journal of Neurology·Nikolai AxmacherJuergen Fell
Jun 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michel Le Van QuyenJerome Engel
Sep 15, 2009·Nature Neuroscience·Gabrielle GirardeauMichaël B Zugaro
Nov 17, 2009·Nature Neuroscience·Marlene R Cohen, John H R Maunsell
May 5, 2012·Science·Shantanu P JadhavLoren M Frank
Dec 15, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bernhard P StaresinaArjen Alink
Apr 19, 2013·Nature·Brad E Pfeiffer, David J Foster
Dec 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lorena DeukerNikolai Axmacher
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Robert B YaffeKareem A Zaghloul
Mar 31, 2017·Nature·Dmitriy AronovDavid W Tank
Nov 3, 2017·Human Brain Mapping·Michael S TrottaKareem A Zaghloul
Sep 30, 2018·Trends in Cognitive Sciences·György Buzsáki, David Tingley
Oct 7, 2018·Nature Communications·Hui ZhangNikolai Axmacher
Oct 26, 2018·Nature Reviews. Neuroscience·Hannah R Joo, Loren M Frank
Jun 15, 2019·Science·Antonio Fernández-RuizGyörgy Buzsáki
Jul 10, 2019·Cell·Yunzhe LiuTimothy E J Behrens
Aug 10, 2019·Science·Thomas M NormanJonathan S Weissman

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Citations

Jul 28, 2020·AJOB Neuroscience·Walter J KoroshetzChristine Grady
Sep 12, 2020·Sleep Medicine·S M RomanellaE Santarnecchi
Feb 17, 2021·Nature Communications·Charles W DickeyEric Halgren
Sep 23, 2020·Sleep·Krishna MelnatturPaul J Shaw
Mar 2, 2021·Sleep Advances : a Journal of the Sleep Research Society·Graham FindlayChiara Cirelli
Apr 10, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yiyao ZhangGyörgy Buzsáki
May 1, 2021·Brain Sciences·Jan SchönbergerJulia Jacobs
Jun 20, 2021·Science Advances·James E KragelJoel L Voss
Oct 13, 2020·Trends in Neurosciences·Serra E FavilaBrice A Kuhl
Aug 10, 2021·Neuroscience and Biobehavioral Reviews·Lennart WittkuhnNicolas W Schuck
Sep 15, 2021·ELife·Davide SpallaAlessandro Treves
Nov 4, 2021·Current Biology : CB·Daniel BushNeil Burgess

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