Replay of Episodic Memories in the Rat

Current Biology : CB
Danielle Panoz-BrownJonathon D Crystal

Abstract

Vivid episodic memories in people have been characterized as the replay of multiple unique events in sequential order [1-3]. The hippocampus plays a critical role in episodic memories in both people and rodents [2, 4-6]. Although rats remember multiple unique episodes [7, 8], it is currently unknown if animals "replay" episodic memories. Therefore, we developed an animal model of episodic memory replay. Here, we show that rats can remember a trial-unique stream of multiple episodes and the order in which these events occurred by engaging hippocampal-dependent episodic memory replay. We document that rats rely on episodic memory replay to remember the order of events rather than relying on non-episodic memories. Replay of episodic memories survives a long retention-interval challenge and interference from the memory of other events, which documents that replay is part of long-term episodic memory. The chemogenetic activating drug clozapine N-oxide (CNO), but not vehicle, reversibly impairs episodic memory replay in rats previously injected bilaterally in the hippocampus with a recombinant viral vector containing an inhibitory designer receptor exclusively activated by a designer drug (DREADD; AAV8-hSyn-hM4Di-mCherry). By contras...Continue Reading

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Citations

Jul 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tao JinFeifei Wang
Jul 30, 2020·Journal of the Experimental Analysis of Behavior·Mark GalizioKatherine Bruce
Oct 26, 2018·Nature Reviews. Neuroscience·Hannah R Joo, Loren M Frank
Dec 20, 2019·Journal of the Experimental Analysis of Behavior·C R Gallistel, E B Papachristos
Aug 15, 2018·Learning & Behavior·Thomas R Zentall
Jul 25, 2019·Frontiers in Human Neuroscience·Michael C Corballis
May 7, 2020·Frontiers in Psychology·Michael C Corballis
Jun 28, 2020·Scientific Reports·Claudia FugazzaÁdám Miklósi
Oct 7, 2020·Journal of Neuroscience Methods·Ana Paula de Castro AraujoFlávio Freitas Barbosa
Sep 29, 2019·Neuropsychologia·Michael C Corballis
Feb 2, 2021·Frontiers in Behavioral Neuroscience·Maria Augustta Sobral de França MalheirosFlávio Freitas Barbosa
Feb 7, 2021·Scientific Reports·Nina KettlerMichael Taborsky
Mar 18, 2021·Learning & Behavior·Alexandra NosarzewskaThomas R Zentall
May 20, 2020·Current Biology : CB·Jonathon D Crystal
Jul 6, 2021·Brain Communications·Joseph I TracyMichael R Sperling
Jul 19, 2020·Neuroscience Research·Satoshi HirataYuji Ikegaya
Aug 18, 2021·Proceedings. Biological Sciences·Alexandra K SchnellChristelle Jozet-Alves

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