PMID: 9160249May 1, 1997Paper

Replenishment of docosahexaenoic acid in n-3 fatty acid-deficient fetal rats by intraamniotic ethyl-docosahexaenoate administration

Journal of Neuroscience Research
P GreenE Yavin

Abstract

A procedure for intraamniotic ethyl-docosahexaenoate (Et-DHA) administration was used to restore the docosahexaenoic acid (DHA; 22:6 n-3) levels in n-3-deficient fetal rats. The state of deficiency, characterized by a 34% and 60% decrease in DHA content of fetal brain and liver, respectively, was attained by feeding the pregnant dams from day 8 and up to 20 days gestation, with an n-3 linolenic acid-deprived diet. After a single intraamniotic administration of Et-DHA on day 18 or 19, a rapid increase in both fetal brain and liver DHA was achieved. This increase was accompanied by a decrease in the docosapentaenoic acid (DPA; 22:5 n-6) level. After 48 hr following Et-DHA administration, the major phospholipids (PLs) phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PC), together accounting for more than 90% of total lipid phosphorus in sunflower oil (SFO)-treated animals, regained the DHA content to levels similar to control animals in both fetal brain and liver tissues. Unlike brain, however, most of the DHA content in liver PLs was restored by 24 hr, suggesting that the fetal liver may have a higher metabolic turnover. The DHA/DPA ratio was used to assess the degree of DHA correction. Fetal brain...Continue Reading

References

Feb 28, 1976·Lancet·M A CrawfordG Williams
Mar 30, 1978·Biochimica Et Biophysica Acta·T Taki, J N Kanfer
Oct 1, 1978·Analytical Biochemistry·A Hara, N S Radin
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·P E Wainwright
Jan 1, 1991·Progress in Lipid Research·S M Innis
Jan 1, 1988·Annual Review of Nutrition·M NeuringerW E Connor
Jan 1, 1988·World Review of Nutrition and Dietetics·P Budowski
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M NeuringerS Luck
Jan 1, 1985·Progress in Lipid Research·P S Sastry
Nov 18, 1974·Biochimica Et Biophysica Acta·C GalliR Paoletti
Oct 1, 1982·Journal of Neurochemistry·M A Samulski, B L Walker
Jan 1, 1995·Molecular Membrane Biology·N Salem, C D Niebylski
Jan 1, 1994·World Review of Nutrition and Dietetics·S E CarlsonW M Wilson
Jan 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J M BourreM Piciotti
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S E CarlsonE A Tolley

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