Repletion of n-3 fatty acid deficient dams with alpha-linolenic acid: effects on fetal brain and liver fatty acid composition.

Lipids
Akiko HaraumaToru Moriguchi

Abstract

Docosahexaenoic acid (DHA) supply to the fetal brain depends upon the dam's dietary intake of n-3 fats. In this study, we measured the incorporation of DHA into the fetal brain and liver in n-3 fatty acid deficient (0.1% alpha-linolenate) mice upon switching to an n-3 fatty acid adequate (2.1% alpha-linolenate) diet. Second generation mice raised and maintained on an n-3 deficient diet during mating were switched to an n-3 adequate diet on embryonic day 1 (ED 1) or ED 13. Fatty acid analysis was performed on fetal brains and livers and on maternal serum on ED 13, 15, 17, and 19. Although fetal brain and liver DHA began at a very low level (both exhibited an 85% decline), recovery was nearly complete by ED 15 in the group switched near conception but thereafter diverged. The maternal serum and fetal liver were very similar in their DHA and docosapentaenoic acid time courses. However, when repletion began on ED 13, brain DHA recovery was only about 44%. These results suggest that a nutritional intervention with alpha-linolenic acid can nearly but incompletely rescue the mouse fetal DHA deficiency if began at the time of conception but that the third trimester is too late, thus leaving a large DHA gap.

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Citations

Nov 15, 2012·The British Journal of Nutrition·Heidi J UrwinParveen Yaqoob
Aug 8, 2013·Free Radical Biology & Medicine·Katie M Lebold, Maret G Traber
Sep 3, 2014·Neurobiology of Learning and Memory·Eldin JašarevićDavid C Geary
Nov 20, 2016·Journal of Lipid Research·Anna M PauterAnders Jacobsson
Sep 22, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mihai D NiculescuCorneliu N Craciunescu
Dec 7, 2019·Progress in Lipid Research·Paul L Else

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