PMID: 9446846Mar 7, 1998Paper

Repletion of the plasma pool of nutrient transport proteins occurs at different rates during the nutritional rehabilitation of severely malnourished children

The Journal of Nutrition
J F MorleseF Jahoor

Abstract

Increased morbidity and mortality are associated with lower plasma protein concentrations in children with severe protein-energy malnutrition. However, the kinetic changes responsible for repletion of the plasma pools of nutrient transport proteins and the rapidity of their replenishment in these children have not been determined. This study was undertaken to determine whether an increased rate of synthesis is the mechanism responsible for repletion of the plasma retinol-binding protein, transthyretin and high density lipoprotein-apolipoprotein A1 concentrations of children with severe malnutrition during nutritional rehabilitation. The plasma concentrations and synthesis rates of retinol-binding protein, transthyretin and high density lipoprotein-apolipoprotein A1 were measured using a constant intragastric infusion of 2H3-leucine in 22 children with severe protein-energy malnutrition, at approximately 2 d postadmission (study 1), approximately 8 d post-admission when infections were under control (study 2) and approximately 59 d postadmission at recovery (study 3). In study 1 the plasma concentrations and rates of synthesis of all the proteins were lower compared with values at recovery. In study 2, retinol-binding protein an...Continue Reading

References

Aug 18, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y IngenbleekM De Visscher
Jan 1, 1976·The American Journal of Clinical Nutrition·P Viart
Jan 15, 1987·Biochemical and Biophysical Research Communications·R BarbarasG Ailhaud
Sep 1, 1968·The Journal of Clinical Investigation·W P James, A M Hay
Sep 1, 1968·The Journal of Clinical Investigation·M KanaiD S Goodman
Jul 1, 1969·The American Journal of Clinical Nutrition·D S McLarenS Shadarevian
Feb 1, 1994·Journal of Pediatric Gastroenterology and Nutrition·D BrasseurJ Duchateau
Dec 1, 1996·The American Journal of Clinical Nutrition·J F MorleseF Jahoor
Aug 1, 1997·The Journal of Nutrition·J F MorleseF Jahoor

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Citations

Jun 5, 2013·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Suzie Ferrie, Margaret Allman-Farinelli
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Yves Ingenbleek, Vernon R Young
May 31, 2008·Annals of Tropical Paediatrics·Farook JahoorTerrence Forrester

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