Replicating and Cycling Stores of Information Perpetuate Life

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Antony M Jose

Abstract

Life is perpetuated through a single-cell bottleneck between generations in many organisms. Here, I highlight that this cell holds information in two distinct stores: in the linear DNA sequence that is replicated during cell divisions, and in the three-dimensional arrangement of molecules that can change during development but is recreated at the start of each generation. These two interdependent stores of information - one replicating with each cell division and the other cycling with a period of one generation - coevolve while perpetuating an organism. Unlike the genome sequence, the arrangement of molecules, including DNA, RNAs, proteins, sugars, lipids, etc., is not well understood. Because this arrangement and the genome sequence are transmitted together from one generation to the next, analysis of both is necessary to understand evolution and origins of inherited diseases. Recent developments suggest that tools are in place to examine how all the information to build an organism is encoded within a single cell, and how this cell code is reproduced in every generation. See also the video abstract here: https://youtu.be/IdWEL-T6TPU.

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Citations

Apr 22, 2020·Journal of the Royal Society, Interface·Antony M Jose
Apr 23, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Antony M Jose
Sep 15, 2018·Communicative & Integrative Biology·František Baluška, William B Miller
Jul 11, 2021·Nature Communications·Sindhuja DevanapallyAntony M Jose

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