Replication and validation of higher order models demonstrated that a summary score for the EORTC QLQ-C30 is robust

Journal of Clinical Epidemiology
Johannes M GiesingerEORTC Quality of Life Group

Abstract

To further evaluate the higher order measurement structure of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30), with the aim of generating a summary score. Using pretreatment QLQ-C30 data (N = 3,282), we conducted confirmatory factor analyses to test seven previously evaluated higher order models. We compared the summary score(s) derived from the best performing higher order model with the original QLQ-C30 scale scores, using tumor stage, performance status, and change over time (N = 244) as grouping variables. Although all models showed acceptable fit, we continued in the interest of parsimony with known-groups validity and responsiveness analyses using a summary score derived from the single higher order factor model. The validity and responsiveness of this QLQ-C30 summary score was equal to, and in many cases superior to the original, underlying QLQ-C30 scale scores. Our results provide empirical support for a measurement model for the QLQ-C30 yielding a single summary score. The availability of this summary score can avoid problems with potential type I errors that arise because of multiple testing when making comparisons based on the 15 outcomes generate...Continue Reading

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Citations

Aug 16, 2016·The Breast : Official Journal of the European Society of Mastology·Philip M P PoortmansLorenzo Livi
Feb 15, 2017·Psycho-oncology·Hannah MatthewsElizabeth A Grunfeld
Jun 8, 2017·Japanese Journal of Clinical Oncology·Maik ThiemeAndreas Hinz
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Feb 6, 2020·Cancer Medicine·Sarah SchroyenStéphane Adam
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Jul 14, 2020·Journal of Cancer Survivorship : Research and Practice·A van der HoutI M Verdonck-de Leeuw
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Sep 25, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Malin Sternby EilardMagnus Rizell

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