Replication-dependent histone isoforms: a new source of complexity in chromatin structure and function

Nucleic Acids Research
Rajbir SinghMark R Parthun

Abstract

Replication-dependent histones are expressed in a cell cycle regulated manner and supply the histones necessary to support DNA replication. In mammals, the replication-dependent histones are encoded by a family of genes that are located in several clusters. In humans, these include 16 genes for histone H2A, 22 genes for histone H2B, 14 genes for histone H3, 14 genes for histone H4 and 6 genes for histone H1. While the proteins encoded by these genes are highly similar, they are not identical. For many years, these genes were thought to encode functionally equivalent histone proteins. However, several lines of evidence have emerged that suggest that the replication-dependent histone genes can have specific functions and may constitute a novel layer of chromatin regulation. This Survey and Summary reviews the literature on replication-dependent histone isoforms and discusses potential mechanisms by which the small variations in primary sequence between the isoforms can alter chromatin function. In addition, we summarize the wealth of data implicating altered regulation of histone isoform expression in cancer.

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Citations

Jun 21, 2019·Nucleic Acids Research·Mengping LongToyotaka Ishibashi
Apr 8, 2020·Cell & Bioscience·Debparna NandyDebasree Dutta
Nov 10, 2020·Reproduction, Fertility, and Development·Dale McAninchPaul Q Thomas
Jul 25, 2019·Cancer Discovery·Richard L BennettJonathan D Licht
Nov 28, 2020·Genome Génome / Conseil National De Recherches Canada·Dongbo DingToyotaka Ishibashi
Mar 11, 2021·Free Radical Biology & Medicine·José-Luis García-GiménezFederico V Pallardó
Mar 27, 2021·The Journal of Physical Chemistry. B·Daniel EspirituAnna R Panchenko
Apr 9, 2021·Clinical Epigenetics·Stefano AmatoriMirco Fanelli
Apr 24, 2021·Nature Communications·Grigoriy A ArmeevAlexey K Shaytan
Dec 8, 2020·Current Opinion in Genetics & Development·Andrew FlausTom Owen-Hughes

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Methods Mentioned

BETA
sumoylation
dissection
ChIP-Seq

Software Mentioned

PyMOL

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