Replication, neurotropism, and pathogenicity of avian paramyxovirus serotypes 1-9 in chickens and ducks.

PloS One
Shin-Hee KimSiba K Samal

Abstract

Avian paramyxovirus (APMV) serotypes 1-9 have been isolated from many different avian species. APMV-1 (Newcastle disease virus) is the only well-characterized serotype, because of the high morbidity, mortality, and economic loss caused by highly virulent strains. Very little is known about the pathogenesis, replication, virulence, and tropism of the other APMV serotypes. Here, this was evaluated for prototypes strains of APMV serotypes 2-9 in cell culture and in chickens and ducks. In cell culture, only APMV-1, -3 and -5 induced syncytium formation. In chicken DF1 cells, APMV-3 replicated with an efficiency approaching that of APMV-1, while APMV-2 and -5 replicated to lower, intermediate titers and the others were much lower. Mean death time (MDT) assay in chicken eggs and intracerebral pathogenicity index (ICPI) test in 1-day-old SPF chicks demonstrated that APMV types 2-9 were avirulent. Evaluation of replication in primary neuronal cells in vitro as well as in the brains of 1-day-old chicks showed that, among types 2-9, only APMV-3 was neurotropic, although this virus was not neurovirulent. Following intranasal infection of 1-day-old and 2-week-old chickens, replication of APMV types 2-9 was mostly restricted to the respirat...Continue Reading

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Citations

Jul 25, 2014·Avian Diseases·Fernando EsperónMaría Jesús Muñoz
Feb 6, 2016·Virology Journal·Kobey KaramendinMarat Sayatov
Apr 30, 2015·Transboundary and Emerging Diseases·P GogoiS Kumar
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May 23, 2017·Frontiers in Microbiology·Hyun-Jeong LeeKang-Seuk Choi
Nov 10, 2013·Cancers·Aneta KwiatkowskaMariano S Viapiano
Sep 4, 2018·BioMed Research International·Muhammad Bashir BelloAbdul Rahman Omar
Dec 29, 2017·PloS One·Kobey KaramendinMarat Sayatov

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