PMID: 9650976Jul 3, 1998Paper

Replication of bovine herpesvirus type 4 in human cells in vitro

Journal of Clinical Microbiology
L Egyed

Abstract

A reference strain (Movár 33/63) of bovine herpesvirus type 4 (BHV-4) was inoculated into 14 different human cell lines and five primary cell cultures representing various human tissues. BHV-4 replicated in two embryonic lung cell lines, MRC-5 and Wistar-38, and in a giant-cell glioblastoma cell culture. Cytopathic effect and intranuclear inclusion bodies were observed in these cells. PCR detected a 10,000-times-higher level of BHV-4 DNA. Titration of the supernatant indicated a 100-fold increase of infectious particles. Since this is the first bovine (human herpesvirus 8 and Epstein-Barr virus related) herpesvirus which replicates on human cells in vitro, the danger of possible human BHV-4 infection should not be ignored.

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Citations

Oct 10, 2015·Journal of Feline Medicine and Surgery·Elliott ChiuSue VandeWoude
Jul 21, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Gaetano DonofrioIain Martin Sheldon
Jun 22, 2000·The Journal of General Virology·G DonofrioV L van Santen
Jan 9, 2013·Journal of Cellular Biochemistry·Serena MontagnaroAntonio Giordano
Oct 19, 2005·Cancer Research·Laurent GilletAlain Vanderplasschen
Jan 7, 2021·Archives of Virology·F RomeoAndrea E Verna
Apr 10, 2019·Comparative Immunology, Microbiology and Infectious Diseases·Pedro MoránAndrea Verna

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