Replication of double-stranded RNA in particles of Penicillium stoloniferum virus S.

Nucleic Acids Research
K W Buck

Abstract

RNA polymerase activity was assayed in different particle classes of Penicillium stoloniferum virus S. RNA polymerase activity was found to be associated with H particles, which contain double-stranded RNA and single-stranded RNA, but not with L particles, which contain only double-stranded RNA and not with M particles, which contain only single-stranded RNA. In H particles the reaction occurred with the formation of one new molecule of double-stranded RNA (or two complementary single strands of RNA) per virus particle and the production of product particles (P particles), which contained two molecules of double-stranded RNA (or its equivalent). This RNA polymerase is therefore a replicase, which catalyses the synthesis of the two complementary strands of double-stranded RNA in a single virus particle. This is the first report of this type of RNA polymerase system.

References

May 1, 1975·The Journal of General Virology·K W Buck, G Ratti
Jun 1, 1973·Journal of General Microbiology·P A LemkeS W Pieper
Jun 1, 1973·The Journal of General Virology·H A Wood
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·K MiuraA J Shatkin
Jan 1, 1973·Canadian Journal of Microbiology·C H NashP A Lemke
Mar 1, 1973·The Journal of General Virology·K W Buck, G F Kempson-Jones
Aug 1, 1974·The Journal of General Virology·K F Chater, D H Morgan

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Citations

Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M ImaiY Furuichi
Oct 1, 1976·Nucleic Acids Research·J Bruenn, B Keitz
Oct 1, 1978·Nucleic Acids Research·G Ratti, K W Buck
Jun 11, 1980·Nucleic Acids Research·J D WelshR B Wickner
Jul 11, 1980·Nucleic Acids Research·J BruennW Held
Oct 16, 1978·Biochemical and Biophysical Research Communications·K W Buck
Aug 14, 1978·Biochemical and Biophysical Research Communications·J P Bernard, A M Petitjean
Jan 30, 1981·Biochemical and Biophysical Research Communications·R M McGintyC J Rawlinson
Mar 1, 1986·Journal of Virology·A SriskanthaC P Romaine
Jan 1, 1984·Molecular and Cellular Biology·B S Ben-TzviA Tamarkin

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