PMID: 9194043Jan 1, 1997Paper

Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells

Microbiology and Immunology
Y IkedaT Mikami

Abstract

Feline syncytial virus (FSV) was isolated from feline peripheral blood mononuclear cells of FSV-seropositive cats. When the susceptibility of feline T-lymphocytes to FSV was examined using three strains of FSV, FSV antigens were detected in the FSV-infected T-lymphoblastoid cells. Further, a diversity of biological properties, including replication kinetics and syncytia formation, was noted among the strains, and condensation of chromatin and the fragmentation of cellular DNA were observed in the infected cells. From these data, we conclude that FSV is lymphotropic and can induce apoptosis in the lymphocytes.

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Citations

Dec 5, 1998·Veterinary Immunology and Immunopathology·T MizunoA Hasegawa
Apr 25, 2003·Journal of Virological Methods·Hang T T PhungHiroomi Akashi
Nov 5, 1999·Annual Review of Microbiology·A RoulstonP E Branton
Feb 27, 2018·Journal of Feline Medicine and Surgery·Jessica M Quimby, Dori L Borjesson

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis