PMID: 2494807Jan 1, 1989Paper

Replication of hepatitis B virus with corticosteroid therapy in hepatitis B virus related membranous nephropathy

Virchows Archiv. A, Pathological Anatomy and Histopathology
F M LaiK N Lai

Abstract

The therapeutic effect of corticosteroid in hepatitis B virus (HBV) related membranous nephropathy was investigated in a 29-year-old chronic HBV carrier. Prednisolone (60 mg/day) was given for eight weeks and gradually reduced over the subsequent four months. In the renal biopsies taken before and after corticosteroid therapy, light microscopy revealed progression of sclerosis. Immunofluorescent staining showed glomerular capillary deposition of hepatitis B core antigen (HBcAg) by polyclonal antisera and hepatitis B e antigen (HBeAg) by monoclonal antibodies. Electron microscopy revealed 40-50 nm diameter virus-like particles in the glomeruli only from the biopsy performed after corticosteroid therapy. The serum concentrations of alanine aminotransferase, HBeAg, and HBV DNA increased with corticosteroid therapy suggesting active viral replication despite the absence of overt clinical hepatitis. Renal function did not improve and corticosteroid therapy was apparently not helpful in this patient. Our results conflict with the earlier notion that short-term corticosteroid does not interfere with a favorable outcome of the infection of the related renal disease.

Citations

Jan 11, 2012·Clinical Microbiology Reviews·Jasmine SamalPerumal Vivekanandan
Jun 17, 2011·Nephron. Clinical Practice·Usama ElewaFernando C Fervenza
Aug 31, 2007·Drugs & Aging·Jeroen K J Deegens, Jack F M Wetzels
Feb 6, 2010·World Journal of Gastroenterology : WJG·Yu ZhangFeng-Yu Wang
Mar 1, 2012·World Journal of Gastroenterology : WJG·Xiao-Yong ZhengXiao-Dong Zheng
Jan 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P K LiK N Lai
Mar 4, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·F M LaiK N Lai
Jun 7, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jacques Gilloteaux, Adebowale Afolayan
Jan 18, 2020·Expert Review of Gastroenterology & Hepatology·Yanjun LiuGuangming Li
Apr 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M C Chiu

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