Replication of mengovirus. I. Effect on synthesis of macromolecules by host cell.

Journal of Bacteriology
P G Plagemann, H E Swim

Abstract

Plagemann, Peter G. W. (Western Reserve University, Cleveland, Ohio), and H. Earle Swim. Replication of mengovirus. I. Effect on synthesis of macromolecules by host cell. J. Bacteriol. 91:2317-2326. 1966.-The replication of mengovirus was studied in two strains of Novikoff (rat) hepatoma cells propagated in vitro. The replicative cycle in both strains required 6.5 to 7 hr. Infection resulted in a marked depression of ribonucleic acid (RNA) and protein synthesis by strain N1S1-63. Inhibition of RNA synthesis was reflected by a decrease in the deoxyribonucleic acid (DNA)-dependent RNA polymerase activity of isolated nuclei. Mengovirus had no effect on either protein or RNA synthesis or on the DNA-dependent RNA polymerase activity of a second strain, N1S1-67. The time course of viral-induced synthesis of RNA by cells was studied in cells treated with actinomycin D. It was first detectable between 2.5 and 3 hr after infection and continued until 6.5 to 7 hr. The formation of mature virus was estimated biochemically by measuring the amount of RNA synthesized as a result of viral infection which was resistant to degradation by ribonuclease in the presence of deoxycholate. Approximately 70% of the deoxycholate-ribonuclease-resistant R...Continue Reading

References

Jan 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·H E SWIM, R F PARKER
Aug 1, 1962·Proceedings of the National Academy of Sciences of the United States of America·D BALTIMORE, R M FRANKLIN
Jan 1, 1962·Cold Spring Harbor Symposia on Quantitative Biology·R M FRANKLIN, D BALTIMORE
Dec 19, 1962·Biochemical and Biophysical Research Communications·J J HOLLAND
Nov 27, 1962·Biochemical and Biophysical Research Communications·D BALTIMORE, R M FRANKLIN
Jan 1, 1962·Cold Spring Harbor Symposia on Quantitative Biology·C SCHOLTISSEKW SCHAEFER
Jan 15, 1963·Proceedings of the National Academy of Sciences of the United States of America·J R WARNERA RICH
Mar 15, 1963·Proceedings of the National Academy of Sciences of the United States of America·C WEISSMANNS OCHOA
Mar 1, 1963·Virology·E F ZIMMERMANJ E DARNELL
Oct 1, 1963·Journal of Cellular Physiology·M HOMMA, A F GRAHAM
Apr 1, 1964·Journal of Molecular Biology·J J HOLLAND, J A PETERSON
Jul 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·E REICH TATUMEL
May 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·S PenmanJ E Darnell
Jan 1, 1960·Science·R J Britten, R B Roberts

❮ Previous
Next ❯

Citations

Jan 1, 1973·Archiv für die gesamte Virusforschung·M Korbecki
Mar 1, 1972·Japanese Journal of Microbiology·Y TanakaT Omori
Jul 1, 1979·In Vitro·L S Siegel, R W Bernlohr
Jan 1, 1987·The Journal of Membrane Biology·R P BiegonJ D Sheridan
Jan 1, 1978·Journal of Supramolecular Structure·R MarzP G Plagemann
Jan 1, 1972·Archiv für die gesamte Virusforschung·M Takehara
Feb 1, 1975·Journal of Virology·C W Bond, H E Swim
Dec 1, 1987·Applied and Environmental Microbiology·A M Nasser, T G Metcalf
Nov 1, 1972·Journal of Virology·M B Darnell, P G Plagemann
Jun 27, 1985·Biochimica Et Biophysica Acta·P G Plagemann, R M Wohlhueter
Aug 1, 1970·Applied Microbiology·E C BordenF A Murphy
Nov 1, 1969·Journal of Virology·R Wall, M W Taylor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.