Replication of mengovirus. II. General properties of the viral-induced ribonucleic acid polymerase.

Journal of Bacteriology
P G Plagemann, H E Swim

Abstract

Plagemann, Peter G. W. (Western Reserve University, Cleveland, Ohio), and H. Earle Swim. Replication of mengovirus. II. General properties of the viral-induced ribonucleic acid polymerase. J. Bacteriol. 91:2327-2332. 1966.-Mengovirus induces the appearance of a ribonucleic acid (RNA) polymerase activity in Novikoff hepatoma cells which is readily distinguished from the deoxyribonucleic acid (DNA)-dependent RNA polymerase since it is not inhibited by actinomycin D or deoxyribonuclease, but is inhibited by ammonium sulfate, and is stable at -17 C. The incorporation of uridine into RNA by infected cells in the presence of actinomycin D does not reflect the viral polymerase activity as measured in cell-free preparations. The viral-induced RNA polymerase is produced in a biphasic fashion. Puromycin inhibits the production of viral polymerase, and in its presence the enzyme appears to be unstable between 4 and 6 hr. Puromycin also prevents the secondary rise in polymerase which begins at the end of replicative cycle. Under these conditions, however, the polymerase appears to be stable. The overall data indicated that some unspecified process is responsible for the apparent instability of viral-induced RNA polymerase between 4 and 6 h...Continue Reading

References

Jun 1, 1966·Journal of Bacteriology·P G Plagemann, H E Swim
Aug 1, 1962·Proceedings of the National Academy of Sciences of the United States of America·D BALTIMORE, R M FRANKLIN
Nov 27, 1962·Biochemical and Biophysical Research Communications·D BALTIMORE, R M FRANKLIN
Jun 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·D BALTIMOREI TAMM
Mar 15, 1963·Proceedings of the National Academy of Sciences of the United States of America·C WEISSMANNS OCHOA
Mar 1, 1963·Virology·E F ZIMMERMANJ E DARNELL
Oct 1, 1963·Journal of Cellular Physiology·M HOMMA, A F GRAHAM
Aug 1, 1960·Proceedings of the National Academy of Sciences of the United States of America·S B Weiss
Dec 1, 1962·The Journal of Cell Biology·L Ernster, L C Jones

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Citations

Jan 1, 1975·Archives of Virology·W T Loesch, A Arlinghaus
Jan 1, 1972·Archiv für die gesamte Virusforschung·R B ArlinghausW T Loesch
Feb 1, 1975·Journal of Virology·C W Bond, H E Swim
Jun 1, 1970·Journal of Virology·B W MahyR D Barry
Sep 1, 1970·Journal of Virology·B W Mahy, P A Bromley
Jun 1, 1966·Journal of Bacteriology·P G Plagemann, H E Swim
Jan 1, 1967·Virology·W McCormick, S Penman
Feb 14, 1968·Journal of Molecular Biology·H B Levy, W A Carter

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