Replication study of 34 common SNPs associated with prostate cancer in the Romanian population

Journal of Cellular and Molecular Medicine
Viorel JingaDana Mates

Abstract

Prostate cancer is the third-most common form of cancer in men in Romania. The Romanian unscreened population represents a good sample to study common genetic risk variants. However, a comprehensive analysis has not been conducted yet. Here, we report our replication efforts in a Romanian population of 979 cases and 1027 controls, for potential association of 34 literature-reported single nucleotide polymorphisms (SNPs) with prostate cancer. We also examined whether any SNP was differentially associated with tumour grade or stage at diagnosis, with disease aggressiveness, and with the levels of PSA (prostate specific antigen). In the allelic analysis, we replicated the previously reported risk for 19 loci on 4q24, 6q25.3, 7p15.2, 8q24.21, 10q11.23, 10q26.13, 11p15.5, 11q13.2, 11q13.3. Statistically significant associations were replicated for other six SNPs only with a particular disease phenotype: low-grade tumour and low PSA levels (rs1512268), high PSA levels (rs401681 and rs11649743), less aggressive cancers (rs1465618, rs721048, rs17021918). The strongest association of our tested SNP's with PSA in controls was for rs2735839, with 29% increase for each copy of the major allele G, consistent with previous results. Our resul...Continue Reading

References

May 10, 2006·Nature Genetics·Laufey T AmundadottirKari Stefansson
Oct 3, 2006·Nucleic Acids Research·Igor V KutyavinWalt Mahoney
Apr 3, 2007·Nature Genetics·Meredith YeagerGilles Thomas
Feb 12, 2008·Nature Genetics·Gilles ThomasStephen J Chanock
Feb 12, 2008·Nature Genetics·Rosalind A EelesDouglas F Easton
Feb 12, 2008·Nature Genetics·Julius GudmundssonKari Stefansson
Jan 20, 2009·Nature Genetics·Thorunn RafnarKari Stefansson
Jan 27, 2009·Journal of Surgical Oncology·Frederick L Greene, Leslie H Sobin
Jun 10, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·S Lilly ZhengJianfeng Xu
Sep 22, 2009·Nature Genetics·Ali Amin Al OlamaDouglas F Easton
Sep 22, 2009·Nature Genetics·Meredith YeagerStephen J Chanock
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jianfeng XuWilliam B Isaacs
Dec 17, 2010·Science Translational Medicine·Julius GudmundssonKari Stefansson
Jan 26, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Jesús Pérez-LosadaJian-Hua Mao
Mar 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray
Sep 17, 2013·International Journal of Cancer. Journal International Du Cancer·Aniruddh KashyapUNKNOWN Polish Hereditary Prostate Cancer Consortium
Oct 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Melina ArnoldIsabelle Soerjomataram
Apr 2, 2014·Oncology Research and Treatment·Fan ZhaoZe Yang
Apr 23, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Duleeka W KnipeRichard M Martin

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Citations

Apr 25, 2019·Journal of Cellular Biochemistry·Rouhollah K MotamediMandana Hasanzad
Dec 22, 2017·Journal of Cellular and Molecular Medicine·Paul D IordacheKári Stefánsson
Aug 1, 2018·Frontiers in Physiology·Yu TongDezhi Mu

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Methods Mentioned

BETA
biopsy
genotyping
biopsies

Software Mentioned

Stata MP13
PLINK
R

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