PMID: 6538134Jan 1, 1984Paper

Replication variants of the human inactive X chromosome. II. Frequency and replication rate relative to the other chromosomes of the complement

Chromosoma
M Schmidt, W M Stolzmann

Abstract

Replication variants of the inactive X chromosome were investigated in lymphocytes from six donors by means of terminal BrdU or thymidine incorporation. There were interindividual differences in the incidence of particular variants. In endoreduplicated and tetraploid cells both allocyclic X chromosomes showed the same replication sequence. The Xp22 band of the allocyclic X chromosome seemed to replicate later than the homologous material in some cells. Initiation time of DNA synthesis within the inactive X chromosome was found to be stable; termination time, however, varied greatly relative to the other chromosomes. Early completion of replication within the heterochromatic X chromosome could be demonstrated preferentially for the Xq25-27 terminal sequence, but other variants expressed the phenomenon also. A variable replication rate of the inactive X chromosome is believed to be responsible for its asynchronous, independent replication. The biological significance of the phenomenon is discussed with respect to cell differentiation.

References

Aug 1, 1979·Clinical Genetics·B SantessonA Mattsson
Jan 1, 1978·Experimental Cell Research·R J Andina
Nov 1, 1978·Cell and Tissue Kinetics·C J Smith, J C Allen
Oct 14, 1977·Human Genetics·B K McCaw, S A Latt
Jan 1, 1975·Cytogenetics and Cell Genetics·M A KimK H Grzeschik
Mar 1, 1981·Cancer Genetics and Cytogenetics·S A LattH Lazarus
Jan 1, 1980·Chromosoma·M Schmidt
Jan 1, 1982·Chromosoma·P G Otto, E Therman
Nov 1, 1982·Cell·G HolmquistJ Jordan
Jul 1, 1980·Experimental Cell Research·K E Weber, S F Hoegerman

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Citations

May 1, 1988·Human Genetics·K S ReddyD G Papworth
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M Schmidt, B R Migeon
Dec 1, 1992·Clinical Genetics·M H Kormann-BortolottoT Webb

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