Replicative and differentiative behavior in daughter pairs of myogenic stem cells

Experimental Cell Research
I R Konigsberg, K K Pfister

Abstract

Time-lapse microcinematography was used to trace the migration and subsequent fate of daughter pairs from single myogenic stem cells. The generation times of siblings which divide are closely correlated (r, 0.73) compared with randomly selected cells (r, 0.059), suggesting the more or less equal partition of stem cell components. The commitment to differentiative expression, however, is not inherited and must occur following stem cell division. Within the combined group in which at least one sibling fused, the ratio of pairs in which both fuse to pairs in which one divides and one fuses is 21:18. X2 for this ratio (compared with 1:1) is 0.103 indicating that it is just as likely that one daughter fuses and the other divides as that both fuse. We see no evidence of an intrinsic mitotic clock. If there were, one would expect that both or neither daughter would differentiate, depending on whether or not the 'clock' had run out for a particular stem cell.

References

Mar 1, 1979·Developmental Biology·R B Devlin, C P Emerson
Mar 1, 1978·Developmental Biology·I R KonigsbergL O Mixter
Nov 1, 1975·Quarterly Reviews of Biophysics·H HoltzerM Okayama
Apr 25, 1975·Journal of Molecular Biology·C P Emerson, S K Beckner
Sep 1, 1971·Developmental Biology·I R Konigsberg
Dec 1, 1972·Developmental Biology·M C O'Neill, F E Stockdale
Mar 1, 1974·Developmental Biology·P A Buckley, I R Konigsberg
Jan 1, 1972·The Journal of Cell Biology·M C O'Neill, F E Stockdale
Jan 1, 1980·Journal of Supramolecular Structure·T A LinkhartS D Hauschka
Oct 1, 1983·Developmental Biology·W M Sutherland, I R Konigsberg
Jan 1, 1983·Developmental Biology·B H Devlin, I R Konigsberg
Jan 1, 1983·Differentiation; Research in Biological Diversity·L S Quinn, M Nameroff
Dec 1, 1962·Experimental Cell Research·J R COOK, B COOK
Jun 21, 1963·Science·I R KONIGSBERG
Apr 1, 1965·Experimental Cell Research·K B DAWSONE O FIELD
Nov 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·I R KONIGSBERG

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Citations

May 4, 2013·Skeletal Muscle·Sean M Gross, Peter Rotwein
Jul 29, 2003·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Serguei V PlotnikovNelly A Odintsova

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