Sep 7, 1990

Replicative senescence: the human fibroblast comes of age

Science
S Goldstein

Abstract

Human diploid fibroblasts undergo replicative senescence predominantly because of arrest at the G1/S boundary of the cell cycle. Senescent arrest resembles a process of terminal differentiation that appears to involve repression of proliferation-promoting genes with reciprocal new expression of antiproliferative genes, although post-transcriptional factors may also be involved. Identification of participating genes and clarification of their mechanisms of action will help to elucidate the universal cellular decline of biological aging and an important obverse manifestation, the rare escape of cells from senescence leading to immortalization and oncogenesis.

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Mentioned in this Paper

Cell Aging
Specimen Type - Fibroblasts
Transcription, Genetic
Immortalization
Biological Aging
Terminal Differentiation
Senescence Function
Cell Cycle
Chromosomes
Fibroblasts

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