Report of a Delphi exercise to inform the design of a research programme on screening for thoracic aortic disease.

Trials
R G AbbascianoAortic Dissection Awareness Day UK 2019 Working Group

Abstract

To inform the design of a clinical trial of a targeted screening programme for relatives of individuals affected by thoracic aortic disease, we performed a consensus exercise as to the acceptability of screening, the optimal sequence and choice of tests, long-term patient management, and choice of trial design. Working with the Aortic Dissection Awareness UK & Ireland patient association, we performed a Delphi exercise with clinical experts, patients, and carers, consisting of three rounds of consultation followed by a final multi-stakeholder face-to-face workshop. Thirty-five experts and 84 members of the public took part in the surveys, with 164 patients and clinicians attending the final workshop. There was substantial agreement on the need for a targeted screening pathway that would employ a combined approach (imaging + genetic testing). The target population would include the first- and second-degree adult (> 15 years) relatives, with no upper age limit of affected patients. Disagreement persisted about the screening process, sequence, personnel, the imaging method to adopt, computed tomography (CT) scan vs magnetic resonance imaging (MRI), and the specifics of a potential trial, including willingness to undergo randomisat...Continue Reading

References

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Mar 4, 2014·Journal of Clinical Epidemiology·Ivan R DiamondPaul W Wales
Jul 4, 2016·International Journal of Cardiology·Elizabeth N RobertsonRichmond W Jeremy
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Methods Mentioned

BETA
dissection
dissects
imaging technique

Clinical Trials Mentioned

NCT03861741

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