Report of selective cortical infarcts in the primate clot model of vasospasm after subarachnoid hemorrhage

Neurosurgery
Bawarjan SchatloRyszard M Pluta

Abstract

In human autopsy studies, 70% to 80% of patients with aneurysmal subarachnoid hemorrhage (SAH) showed infarcts in cerebral cortex covered by subarachnoid blood. Thus far, no animal model of SAH is known to produce this peculiar infarct pattern, and its pathogenesis remains enigmatic. To investigate whether such infarcts occur in the clot model of SAH in primates. We performed a retrospective pathological review of 16 primate brains. In 13 cynomolgus monkeys, a blood clot was placed around the middle cerebral artery after additional removal of the arachnoid membrane from the basal surface of the frontal and temporal cortexes. Three animals underwent sham surgery without placement of a blood clot (controls). The brains were harvested between days 1 and 28 after SAH and examined by a neuropathologist blinded to study group. We identified 2 types of cortical infarcts. A band of selective cortical laminar necrosis parallel to the cortical surface ("horizontal") was found in 5 animals. The second category of cortical lesions had a "vertical" extension. It included wedge-shaped (n = 2) or pillarlike (n = 2) necrosis. Both horizontal and vertical infarcts were located exclusively in areas adjacent to subarachnoid blood. The presence of...Continue Reading

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Citations

May 18, 2013·Journal of Neurology·Annerose ZieglerStefanie Leistner
Sep 14, 2014·Translational Stroke Research·Ryszard M PlutaVictoria Hoffmann
Jun 19, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jens P DreierJed A Hartings
Mar 31, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maren Kl WinklerJens P Dreier
Oct 4, 2017·Brain : a Journal of Neurology·Jed A HartingsJens P Dreier

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