Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells

Transplantation
Jon S OdoricoAnn Adams

Abstract

Beta cell replacement has the potential to restore euglycemia in patients with insulin-dependent diabetes. Although great progress has been made in establishing allogeneic islet transplantation from deceased donors as the standard of care for those with the most labile diabetes, it is also clear that the deceased donor organ supply cannot possibly treat all those who could benefit from restoration of a normal beta cell mass, especially if immunosuppression were not required. Against this background, the International Pancreas and Islet Transplant Association in collaboration with the Harvard Stem Cell Institute, the Juvenile Diabetes Research Foundation (JDRF), and the Helmsley Foundation held a 2-day Key Opinion Leaders Meeting in Boston in 2016 to bring together experts in generating and transplanting beta cells derived from stem cells. The following summary highlights current technology, recent significant breakthroughs, unmet needs and roadblocks to stem cell-derived beta cell therapies, with the aim of spurring future preclinical collaborative investigations and progress toward the clinical application of stem cell-derived beta cells.

References

Jul 21, 2010·Nature·K KimG Q Daley
Jul 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A M PosseltP G Stock
Feb 23, 2012·Endocrinology·Chengyang LiuMichael R Rickels
Oct 13, 2012·Nature Reviews. Immunology·Leonard D ShultzDale L Greiner
Mar 12, 2013·Cell Stem Cell·Sayaka WakayamaTeruhiko Wakayama
Jun 21, 2013·Annals of Surgery·Giuseppe OrlandoRobert J Stratta
Jun 27, 2013·Journal of Medical Primatology·Yasufumi ShirasakiToshiaki Hayashi
Oct 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Barbara LudwigStefan R Bornstein
Mar 1, 2014·Nature Protocols·Uri Ben-David, Nissim Benvenisty
Jul 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Alice A TomeiJeffrey A Hubbell
Sep 12, 2014·Nature Biotechnology·Alireza RezaniaTimothy J Kieffer
Oct 11, 2014·Cell·Felicia W PagliucaDouglas A Melton
Feb 20, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T ChenM C Poznansky
Mar 31, 2015·European Journal of Pharmacology·Melanie L Graham, Henk-Jan Schuurman
Apr 1, 2015·European Journal of Pharmacology·Melanie L Graham, Mark J Prescott
Oct 13, 2015·Science·Luhan YangGeorge Church
Oct 23, 2015·Diabetologia·Cornelis R van der TorrenBart O Roep
Nov 7, 2015·Regenerative Medicine·Sheyna GiffordGiuseppe Orlando
Nov 21, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L L KenneyM A Brehm
Nov 27, 2015·Science Translational Medicine·Jeffrey A BluestoneQizhi Tang
Dec 4, 2015·Science Translational Medicine·Jennifer E BruinTimothy J Kieffer
Mar 22, 2016·Lab on a Chip·Mohammad NourmohammadzadehYong Wang
Apr 3, 2016·Trends in Endocrinology and Metabolism : TEM·Daniel Pipeleers, Bart Keymeulen
Apr 12, 2016·The Journal of Clinical Investigation·Chunhua DaiAlvin C Powers
Jun 4, 2016·Cell Stem Cell·Timothy J Kieffer

❮ Previous
Next ❯

Citations

Apr 21, 2018·Transplantation·A M James Shapiro
Sep 25, 2018·Current Opinion in Organ Transplantation·Elisabeth Kemter, Eckhard Wolf
Mar 13, 2020·Frontiers in Cell and Developmental Biology·Thomas Aga LegøySimona Chera
Jun 5, 2020·Stem Cell Research & Therapy·Deepa Bhartiya, Subhan Ali Mohammad
Apr 24, 2020·Science Translational Medicine·Kristina G MaxwellJeffrey R Millman
Aug 11, 2020·Current Opinion in Organ Transplantation·Taylor M CoeCharles G Rickert
Apr 18, 2020·Expert Opinion on Biological Therapy·Cristian LoretelliPaolo Fiorina
Sep 9, 2020·Nature Metabolism·Thierry Berney, Ekaterine Berishvili
Sep 4, 2020·Stem Cell Reviews and Reports·Mohamed A GhoneimMahmoud M Zakaria
Jan 24, 2021·Advanced Drug Delivery Reviews·Bhushan N KharbikarTejal A Desai
Nov 22, 2020·International Journal of Molecular Sciences·Felipe ArroyaveFernando Lizcano
Mar 3, 2021·Current Opinion in Organ Transplantation·Riccardo Tamburrini, Jon S Odorico
Feb 5, 2019·Advanced Drug Delivery Reviews·Alexander U ErnstMinglin Ma
Sep 20, 2019·Lancet·Marie-Christine VantyghemMichael R Rickels
May 25, 2021·Acta Diabetologica·Lorenzo Piemonti
Jun 10, 2021·American Journal of Physiology. Cell Physiology·Nathaniel J HartRonald M Lynch
Jun 23, 2021·Trends in Endocrinology and Metabolism : TEM·Andreas Alvin Purnomo SoetedjoAdrian Kee Keong Teo
Jul 3, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ronald F ParsonsUNKNOWN ASTS Cellular Transplantation Committee
Jul 31, 2021·Science·Todd M BruskoCherie L Stabler
Sep 16, 2021·Islets·Katerina BittenglovaTomas Koblas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cambridge Stem Cell Institute - Researcher Network

Cambridge Stem Cell Institute's mission is to transform human health through a deep understanding of stem cell biology. Follow this feed to stay up to date on research published in this group.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.