Report of two fatal cases of Mycobacterium mucogenicum central nervous system infection in immunocompetent patients

Journal of Clinical Microbiology
Toïdi AdékambiMichel Drancourt

Abstract

Neurological infections due to rapidly growing mycobacteria (RGM) have rarely been reported. We recently investigated two unrelated immunocompetent patients, one with community-acquired lymphocytic meningitis and the other with cerebral thrombophlebitis. Mycobacterium mucogenicum was isolated in pure culture and detected by PCR sequencing of cerebrospinal fluid samples. Both patients eventually died. The two isolates exhibited an overlapping antimicrobial susceptibility pattern. They were susceptible in vitro to tetracyclines, macrolides, quinolones, amikacin, imipenem, cefoxitin, and trimethoprim-sulfamethoxazole and resistant to ceftriaxone. They shared 100% 16S rRNA gene sequence similarity with M. mucogenicum ATCC 49650T over 1,482 bp. Their partial rpoB sequences shared 97.8% and 98.1% similarity with M. mucogenicum ATCC 49650T, suggesting that the two isolates were representative of two sequevars of M. mucogenicum species. This case report should make clinicians aware that M. mucogenicum, an RGM frequently isolated from tap water or from respiratory specimens and mostly without clinical significance, can even be encountered in the central nervous system of immunocompetent patients.

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Citations

Jul 8, 2009·Applied and Environmental Microbiology·Sarah D PerkinsLargus T Angenent
Oct 6, 2006·Journal of Clinical Microbiology·Toïdi AdékambiMichel Drancourt
Feb 10, 2009·International Journal of Hygiene and Environmental Health·Iskandar Ben SalahMichel Drancourt
Sep 19, 2007·American Journal of Clinical Pathology·Xiang Y HanKalen L Jacobson
Oct 18, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·R J MaybrookM E Levi
Oct 23, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T Adékambi
Aug 15, 2015·History of the Human Sciences·Ansgar Allen, Roy Goddard
Mar 11, 2011·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Haruki HaraguchiKaoru Nagata
Feb 12, 2009·Journal of Food Protection·Jorge F Cerna-CortésJorge A González-y-Merchand
Sep 17, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Aishwarya SwainArchana Pan
Dec 10, 2020·Access Microbiology·Salwa MoizUsman Bin Hameed
Dec 24, 2020·Enfermedades Infecciosas Y Microbiologia Clinica·Dioselina Panamá Tristán-SamaniegoAlejandra González-Duarte
Aug 28, 2021·International Journal of Environmental Research and Public Health·Andrés F DávalosBeatriz E Ferro

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