Report on the Sixth International Society of Blood Transfusion Platelet Serology Workshop

Transfusion
G Teramura, S J Slichter

Abstract

The Sixth International Society of Blood Transfusion Platelet Serology Workshop continued studies to identify methods to detect platelet-specific antigens and antibodies. The study was designed to meet three goals. The first was the establishment of antigen-typed platelet panels and determination of the correlation between serologic and DNA typing of platelet-specific antigens. The second goal was the determination of the proficiency of detecting platelet-specific antibodies by laboratory and by technique. The third goal was the identification of any platelet-specific antibodies present in uncharacterized (unknown) antisera. For platelet-antigen typing, concordance between serologic testing and DNA techniques was 93 percent for oligonucleotide typing and 92 percent for allele-specific restriction site analysis. Agreement between these two was 98 percent. Individual laboratories correctly identified the antibodies contained in coded sera 79 +/- 17 percent of the time. The expected results were obtained from the modified antigen-capture enzyme-linked immunosorbent assay in 75 +/- 46 percent of instances, from the monoclonal antibody-specific immobilization of platelet antigens assay in 72 +/- 24 percent of instances, from the mix...Continue Reading

Citations

Jun 23, 1999·Transfusion·R A Sacher
Mar 20, 2008·Obstetrical & Gynecological Survey·V M L Serrarens-JanssenE A P Steegers
Sep 1, 1996·Transfusion Medicine·R M MinchintonY Shibata
Aug 15, 1998·Vox Sanguinis·H KrollS Santoso
Feb 12, 2000·Transfusion Medicine Reviews·R M Minchinton

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