Report on the Tenth International Platelet Genotyping and Serology Workshop on behalf of the International Society of Blood Transfusion

Vox Sanguinis
S Panzer

Abstract

The aims of the 10th International Platelet Serology and Genotyping Workshop were to evaluate the proficiency of platelet immunology determinations. There were 40 participants from 25 countries of four continents. Thirty-eight institutions reported results for genotyping, and 38 institutions reported their serological results. For genotyping, EDTA-anticoagulated whole-blood samples were provided (to allow the inclusion of DNA-separation methodology in the analysis) as well as separated DNA of a and b alleles for human platelet antigen (HPA)-1 to -6. For serological evaluations, sera contained allo- and autoantibodies, and for sensitivity testing a standard freeze-dried sample of HPA-5 antibody. All participants reported HPA-1, -2, -3 and -5 genotyping results; HPA-4 was determined in 29 laboratories and HPA-6 in 21. Results from 16 laboratories were concordant with the majority vote for all allotypes, eight institutions reported one deviation, five laboratories two, and nine laboratories three or more deviations. Twelve institutions had no deviation from the majority vote for HPA antibodies, nine had one, three had two, and 14 had three or more deviations. Most laboratories reported a reactivity of the standard anti-HPA-5b samp...Continue Reading

References

Jan 1, 1995·British Journal of Haematology·K UnkelbachV Kiefel
Sep 1, 1995·Transfusion Medicine·S KekomäkiR Kekomäki
Dec 1, 1995·Transfusion Medicine·P MetcalfeW H Ouwehand
Jul 1, 1996·Transfusion·Y NishiyamaH Okamoto
Aug 24, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·P RozmanF H Claas

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Citations

Mar 20, 2008·Obstetrical & Gynecological Survey·V M L Serrarens-JanssenE A P Steegers
Mar 22, 2005·Journal of Immunological Methods·Susanne DöhlingerTobias J Legler
Dec 12, 2007·Vox Sanguinis·Z FoxcroftUNKNOWN 13th International Society of Blood Transfusion Platelet Immunology Workshop

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