Reported analgesic and anaesthetic administration to rodents undergoing experimental surgical procedures

Laboratory Animals
E L StokesC A Richardson

Abstract

A structured literature review was carried out to assess recent trends in the administration of analgesics and anaesthetics to laboratory rats and mice undergoing surgical procedures. The ScienceDirect database was used to systematically identify studies published in peer-reviewed journals over two periods (2000-2001 and 2005-2006), 86 studies from each time period were included in the review. The total number of animals that underwent surgery, species used, type of procedure, anaesthetic regimen and analgesic administration were noted for each study. There was an increase in the reported administration of systemic analgesics from 10% in 2000-2001 to 20% in 2005-2006. Buprenorphine was the most commonly reported analgesic in both periods (2000-2001: 78%, 2005-2006: 35%) and reporting the use of non-steroidal anti-inflammatory drugs increased from 11% to 53%. There was also a change in reported anaesthetic practices, notably a decrease in the use of pentobarbital and an increase in the use of isoflurane and ketamine/xylazine. Although reported administration of analgesics has increased and there has been some refinement in the selection of anaesthetic agents used, the findings of this review suggest that there is still significa...Continue Reading

References

Apr 25, 2000·Science·D Malakoff
Mar 9, 2004·Journal of the American Veterinary Medical Association·Joanne Paul-MurphyPauline L Wong
May 18, 2004·The Veterinary Record·H E CarlssonJ Hau
Sep 27, 2005·Alternatives to Laboratory Animals : ATLA·Claire A Richardson, Paul A Flecknell
Jun 1, 2004·Alternatives to Laboratory Animals : ATLA·Clément Gauthier

❮ Previous
Next ❯

Citations

Jun 25, 2014·American Journal of Veterinary Research·Jason R HealyJeffrey H Wimsatt
Feb 23, 2011·BMC Veterinary Research·Claire A CoulterClaire A Richardson
Feb 9, 2012·Journal of Visualized Experiments : JoVE·Raquel V FornariBenno Roozendaal
Apr 4, 2013·Journal of the American Veterinary Medical Association·Steven M Niemi
Sep 17, 2015·Journal of Neuroscience Methods·Katie LidsterMark J Prescott
Nov 9, 2011·Respiratory Physiology & Neurobiology·J MooreH J Bell
Jan 5, 2010·The Veterinary Journal·Otto KalliokoskiKlas S P Abelson
Sep 13, 2015·Journal of Pharmacological and Toxicological Methods·Elodie BonfantiPierre Campo
Jul 23, 2009·Journal of Pharmacological and Toxicological Methods·Luka PeternelManica Cerne
Oct 5, 2015·British Journal of Anaesthesia·A G BradburyR E Clutton
Apr 14, 2016·Pain Research and Treatment·Natalie M WilsonFletcher A White
Dec 2, 2010·Basic & Clinical Pharmacology & Toxicology·Petra JacksonKarin S Hougaard
Jan 11, 2011·Veterinary Anaesthesia and Analgesia·R Eddie CluttonPeter J Pascoe
Feb 24, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yusuke OsakiRyuji Kaji
Mar 5, 2015·International Immunopharmacology·P A SarapultsevA P Sarapultsev
Apr 26, 2011·Respiratory Physiology & Neurobiology·Luc J Teppema, Santhosh Baby
Dec 29, 2012·BMC Veterinary Research·Rozemarijn J van der VijverThijs Hendriks
Jul 30, 2015·PloS One·Demelza KoehnMichael G Anderson
Aug 18, 2016·Scientific Reports·Vivian LeungDaniel Sj Pang
Aug 22, 2016·Reproductive Toxicology·M StasinopoulouL H Margaritis
Oct 27, 2016·PloS One·Aurelie ThomasMatthew Leach
Jun 14, 2013·Laboratory Animals·Larry G ThaeteAndrew T Dudley
Mar 23, 2017·Journal of Medical Primatology·Naho KonoikeKatsuki Nakamura
Apr 9, 2017·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Catherine J A WilliamsTobias Wang
Oct 4, 2012·Acta Cirúrgica Brasileira·Carlos Oscar KielingUrsula da Silveira Matte
Oct 12, 2014·Laboratory Animals·Karl A TraulMichael Guarnieri

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.