PMID: 8599925Nov 1, 1995Paper

Reporting of atypical squamous cells of undetermined significance on cervical smears: is it significant?

Diagnostic Cytopathology
S M Selvaggi, H K Haefner

Abstract

A retrospective 7-mo study (June 1, 1993-December 31, 1993) was performed to evaluate the significance of reporting atypical squamous cells of undetermined significance (ASCUS) on cervical smears. During this period 114 (0.7%) of 17,330 smears were diagnosed as ASCUS, 62 of which resulted in either follow-up cervical biopsies and/or endocervical curettages (61%) or repeat smears (39%), and form the basis of this study. Tissue specimens (38 cases) were negative in 24 cases (63%) and were positive in 14 cases (37%). Of the positive specimens, there were 9 low grade squamous intraepithelial lesions (LSIL) and 5 high grade squamous intraepithelial lesions (HSIL). Repeat smears (24 cases) were negative in 19 cases (79%) and were persistent for a lesion in 5 cases (21%). The persistent lesions consisted of 2 ASCUS and 3 LSIL. Overall, of the 62 cases, 43 (69%) were negative and 19 (31%) showed a lesion on follow-up tissue specimens or smears. Of the 62 cases, ASCUS diagnoses included cellular changes suggestive of human papillomavirus infection in 17 (27%) cases, nondiagnostic cellular changes in 16 (26%) cases, atypical squamous metaplasia vs. a squamous intraepithelial lesion (SIL) in 15 (24%) cases, inflammatory cell changes vs. a...Continue Reading

References

Sep 1, 1987·American Journal of Obstetrics and Gynecology·D E JonesJ L Waeltz
Jun 15, 1994·JAMA : the Journal of the American Medical Association·R J KurmanM H Schiffman

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Citations

Dec 1, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S GerberJ F Delaloye
Nov 14, 2002·The Journal of Obstetrics and Gynaecology Research·Saibua B Chichareon, Sathana T Tocharoenvanich
Jun 6, 2000·Journal of Women's Health & Gender-based Medicine·G H Eltabbakh, G D Eltabbakh
Jul 27, 2000·Journal of Clinical Pathology·A al-NafussiE McGoogan
Sep 10, 1998·American Journal of Obstetrics and Gynecology·M F Lachman, C Cavallo-Calvanese
Jul 31, 2001·Diagnostic Cytopathology·R M GatschaP E Saigo
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M A Duggan
Nov 7, 2019·Journal of Obstetrics and Gynaecology of India·Anand N Srivastava, Jata S Misra

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