Reporting of consistency of blood pressure control in randomized controlled trials of antihypertensive drugs: a systematic review of 1372 trial reports.

Journal of Hypertension
Urs FischerPeter M Rothwell

Abstract

Hypertension is a powerful treatable risk factor for stroke. Reports of randomized controlled trials (RCTs) of antihypertensive drugs rightly concentrate on clinical outcomes, but control of blood pressure (BP) during follow-up is also important, particularly given that inconsistent control is associated with a high risk of stroke and that antihypertensive drug classes differ in this regard. We performed a systematic review of reporting of BP control in RCTs of antihypertensive drugs. We searched bibliographic databases (1950-2009) for systematic reviews of RCTs of BP-lowering and identified the main report of all trials. We identified 94 larger trials (>100 participants/arm, >1-year follow-up) and 1278 smaller/shorter trials. Ninety-one (96.8%) larger trials reported some data on mean BP during follow-up, but none reported effects on the consistency of control of BP over time. Although 81 (86.2%) larger trials reported group distribution of BP at baseline (usually SD), only 22 (23.4%) reported such data at any follow-up visit. Eleven (11.7%) larger trials reported group distribution of the change in BP from baseline to follow-up, but 61 (64.9%) reported no data at all on group distribution of BP at follow-up. Thirty-nine (41.5...Continue Reading

References

Aug 12, 2005·BMC Medical Research Methodology·Ellen T CrumleyLisa Hartling
Mar 17, 2010·Lancet Neurology·Peter M RothwellUNKNOWN ASCOT-BPLA and MRC Trial Investigators
Mar 25, 2010·BMJ : British Medical Journal·Kenneth F SchulzUNKNOWN CONSORT Group

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Citations

Mar 3, 2021·The Journal of Clinical Hypertension·Hariprasad EsamAbdul Salam
Apr 13, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Laure RouchUNKNOWN MAPT/DSA Group

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