Reporting on Outcome Measures of Functional Constipation in Children-A Systematic Review

Journal of Pediatric Gastroenterology and Nutrition
Sophie Kuizenga-WesselMerit M Tabbers

Abstract

Standardized outcome measures provide a basis for comparing outcomes of different clinical trials. Consequently, they can serve as the foundation for determining which therapeutic interventions are most effective. The aim of the present study is to systematically assess how definitions and outcome measures are defined in therapeutic randomized controlled trials (RCTs) of children with functional constipation (FC). PubMed, EMBASE, and Cochrane databases were searched. Studies were included if it was a (systematic review of) therapeutic RCT, concerning children from 1 to 18 years old with FC, a definition of FC was provided, and if they were written in English. The Delphi list was used for quality assessment. A total of 4092 articles were found but only 45 studies fulfilled our inclusion criteria. In these 45 trials, 22 different definitions of FC were used (17 studies used the Rome III-criteria), 27 different interventions were investigated, and 29 different definitions of treatment success were used. Thirty RCTs (57%) reported primary outcomes of which treatment success was the most frequently used. Most trials (80%) used parental diaries of which only 2 RCTs stated that their instrument was validated. Twenty-four trials (53%) ...Continue Reading

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Nov 20, 2014·Journal of Pediatric Gastroenterology and Nutrition·Sophie Kuizenga-WesselMerit M Tabbers
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Citations

Sep 15, 2017·Journal of Pediatric Gastroenterology and Nutrition·Noor L H BekkaliMarc A Benninga
Jan 31, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I J N KoppenM A Benninga
May 11, 2018·Clinical Pediatrics·Manu SoodMaria Claudia Perez
Sep 25, 2018·Journal of Pediatric Gastroenterology and Nutrition·Koen HuysentruytUNKNOWN and the BITSS working group
Jan 17, 2017·Expert Review of Gastroenterology & Hepatology·Ilan J N KoppenMarc A Benninga
Nov 30, 2019·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Daiane Oliveira Vale San Gomes, Mauro Batista de Morais
Feb 27, 2020·Expert Review of Gastroenterology & Hepatology·Bridget R Southwell
Aug 12, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P L LuC Di Lorenzo
Apr 11, 2018·BMJ Paediatrics Open·Sophie Kuizenga-WesselMerit Monique Tabbers
Jan 9, 2019·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Kasturi WaingankarBridget R Southwell
Jan 24, 2019·Journal of Pediatric Gastroenterology and Nutrition·Koen HuysentruytUNKNOWN BITSS working group
May 26, 2017·Journal of Pediatric Gastroenterology and Nutrition·Elena ScarpatoAnnamaria Staiano
Sep 26, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S C J NagelkerkeM M Tabbers
Jul 27, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Meghana SatheA Jay Freeman

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