Reporting quality of N-of-1 trials published between 1985 and 2013: a systematic review

Journal of Clinical Epidemiology
Jiang LiRichard Kravitz

Abstract

To evaluate the quality of reporting of single-patient (N-of-1) trials published in the medical literature based on the CONSORT Extension for N-of-1 Trials (CENT) statement and to examine factors that influence reporting quality in these trials. Through a search of 10 electronic databases, we identified N-of-1 trials in clinical medicine published between January 1, 1985, and December 31, 2013. Two reviewers screened articles for eligibility and independently extracted data. Quality assessment was performed using the CENT statement. Discrepancies were resolved by consensus. We identified 112 eligible N-of-1 trials published in 87 journals and involving a total of 2,278 patients. Overall, kappa agreement between the two evaluators for compliance with CENT criteria was 0.80 (95% confidence interval: 0.79, 0.82). Trials assessed pharmacology and therapeutics (87%), behavior (11%), or diagnosis (2%). Although 87% of articles described the trial design (including the planned number of subjects and length of treatment period), the median percentage of specific CENT elements reported in the Methods was 41% (range, 16-87%), and the median percentage in the Results was 38% (range, 32-93%). First authors were predominantly from North Ame...Continue Reading

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Citations

Aug 5, 2017·Journal of the Royal Society of Medicine·R D MirzaG Guyatt
Jan 1, 2017·Methods of Information in Medicine·Martijn De GrootGary Wolf
Nov 5, 2019·Frontiers in Genetics·Elisabetta Rossi, Rita Zamarchi
Jul 30, 2021·Chinese Medicine·Xuan ZhangZhaoxiang Bian
Sep 17, 2021·Pain and Therapy·Wanying HeFengxian Li
Oct 14, 2021·Nature Medicine·Patrick Bodilly KaneJonathan Kimmelman

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