Reports on contrast media reactions: analysis of data from reports to the U.S. Food and Drug Administration

Radiology
E C LasserC C Berry

Abstract

To compare U.S. Food and Drug Administration (FDA) and manufacturer data about patient reactions to ionic and nonionic, low- and high-osmolar contrast media from 1990 through 1994. Reactions to all available high-osmolar and four low-osmolar contrast media (ioxaglate, iohexol, iopamidol, and ioversol) were compared. Ioxaglate is composed of charged particles, and data are reported separately. Reactions were also compared with data from 1980 to 1984, when only high-osmolar contrast media were available. With high-osmolar contrast media compared with the three noncharged low-osmolar media, the incidence (per million examinations) was highest for all reported reactions (193.8 vs 44.4), severe reactions (37.4 vs 10.5), and deaths (3.9 vs 2.1). With high-osmolar media compared with ioxaglate, respectively, the incidence of total reactions was higher (193.8 vs 142.5), of severe reactions was almost the same (37.4 vs 33.6), and of death was lower (3.9 vs 6.4). The incidence of severe reactions to total reactions was higher with nonionic media (23.7%) and ioxaglate (23.6%) than with ionic media (19.3%). The incidence of death to severe reactions was 19.7% with nonionic media, 19.0% with ioxaglate, and 10.4% with high-osmolar media. The...Continue Reading

Citations

Jan 9, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·D E OddJ E Harding
Feb 1, 2013·BMC Medical Informatics and Decision Making·Daiki KobayashiTsuguya Fukui
Sep 14, 2011·International Journal of Nephrology and Renovascular Disease·Doron Sudarsky, Eugenia Nikolsky
May 9, 2014·BioMed Research International·Ulla Ludwig, Frieder Keller
Aug 3, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Vivekanandan KalaiselvanGyanendra Nath Singh
Sep 18, 2014·Journal of Computer Assisted Tomography·Ashley K LotfipourDavid S K Lu
Sep 23, 2014·Journal of Vascular and Interventional Radiology : JVIR·Sean R DariushniaUNKNOWN Society of Interventional Radiology Standards of Practice Committee
May 24, 2003·The British Journal of Radiology·S K Morcos
Sep 24, 2004·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Nancy Costa
Jun 1, 2000·Clinical Reviews in Allergy & Immunology·P L Lieberman, R L Seigle
May 23, 2007·AJR. American Journal of Roentgenology·Jonathan R DillmanSophia C Jan
Sep 23, 2009·AJR. American Journal of Roentgenology·Christopher H HuntGina K Hesley
Jan 25, 2011·AJR. American Journal of Roentgenology·Martin R PrincePaula W Brill
Sep 20, 2002·AJR. American Journal of Roentgenology·Alain-Ferdinand Le BlancheFrank Boudghene
Mar 21, 2003·AJR. American Journal of Roentgenology·Paul J DorioSarah A Shock
Sep 27, 2007·Journal of Computer Assisted Tomography·Dae Young YoonHong Ki Song
Mar 13, 2008·Journal of Cardiovascular Medicine·Alberto RoghiUNKNOWN Atherosclerosis, Thrombosis and Vascular Biology Study Group and the Italian Society for Invasive Cardiology Investigators
Jan 24, 2006·European Radiology·Thomas J VoglR Hammerstingl
Feb 10, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Azriel B OsherovEugenia Nikolsky
Feb 23, 2010·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Maxime FormichiPatrick Noel
Apr 13, 2006·Current Opinion in Nephrology and Hypertension·Neesh Pannu, Marcello Tonelli
Jul 2, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Takahisa Yano
Aug 12, 2009·Cardiovascular and Interventional Radiology·Richard NolzMaria Schoder
Nov 28, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Enrique EsplugasFrancisco Jara
Feb 4, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Marc J Meth, Howard I Maibach
Jul 15, 2015·Experimental and Therapeutic Medicine·Qing ZhangYu-Fen Wu
Jan 25, 2014·BioMed Research International·Antonio PisaniMassimo Sabbatini
Jul 26, 2011·International Journal of Cardiology·Philip Ching Yat WongAidong Zhang
Apr 21, 2009·La Revue de médecine interne·P DewachterO Clément
Mar 31, 2009·Journal of the American College of Radiology : JACR·Hani H AbujudehRathachai Kaewlai

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