Repositioning of Anthelmintic Drugs for the Treatment of Cancers of the Digestive System.

International Journal of Molecular Sciences
Federica LaudisiCarmine Stolfi

Abstract

Tumors of the digestive system, when combined together, account for more new cases and deaths per year than tumors arising in any other system of the body and their incidence continues to increase. Despite major efforts aimed at discovering and validating novel and effective drugs against these malignancies, the process of developing such drugs remains lengthy and costly, with high attrition rates. Drug repositioning (also known as drug repurposing), that is, the process of finding new uses for approved drugs, has been gaining popularity in oncological drug development as it provides the opportunity to expedite promising anti-cancer agents into clinical trials. Among the drugs considered for repurposing in oncology, compounds belonging to some classes of anthelmintics-a group of agents acting against infections caused by parasitic worms (helminths) that colonize the mammalian intestine-have shown pronounced anti-tumor activities and attracted particular attention due to their ability to target key oncogenic signal transduction pathways. In this review, we summarize and discuss the available experimental and clinical evidence about the use of anthelmintic drugs for the treatment of cancers of the digestive system.

References

Feb 8, 1990·The New England Journal of Medicine·C G MoertelJ H Glick
Aug 1, 1988·Clinical Pharmacokinetics·G Edwards, A M Breckenridge
Aug 26, 1983·Science·W C CampbellT A Jacob
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J O'ConnellA Figueredo
Aug 4, 1998·Antimicrobial Agents and Chemotherapy·C M TheodosS Tzipori
Jun 16, 2000·Journal of the South African Veterinary Association·G E Swan
May 1, 1963·The Journal of Surgical Research·T J MCNAIRJ A DEPEYSTER
Aug 3, 2004·Nature Reviews. Drug Discovery·Ted T Ashburn, Karl B Thor
Jul 14, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M MusherJean-Francois Rossignol
Dec 5, 2006·Oncogene·S Segditsas, I Tomlinson
Aug 9, 2008·International Journal of Cancer. Journal International Du Cancer·Joachim MüllerAndrew Hemphill
Feb 4, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Roger Collier
Oct 5, 2010·Nature Chemical Biology·Curtis A ThorneEthan Lee
Mar 2, 2012·Nature Reviews. Drug Discovery·Jack W ScannellBrian Warrington
May 23, 2012·Trends in Parasitology·Richard J MartinCédric Neveu
Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R LabiancaUNKNOWN ESMO Guidelines Working Group
Oct 19, 2013·Journal of Cancer Research and Clinical Oncology·Peter NygrenRolf Larsson
Jul 26, 2014·International Journal of Colorectal Disease·Armin WiegeringChristoph Otto
Aug 12, 2014·Antiviral Research·Jean-François Rossignol
Dec 30, 2014·Current Cancer Drug Targets·Veronika HanusovaPetra Matouskova
Sep 1, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Laine Celestino PintoRaquel Carvalho Montenegro
Oct 21, 2015·Nature Reviews. Clinical Oncology·Francesco BertoliniGauthier Bouche
Dec 29, 2015·Biochemical and Biophysical Research Communications·Meifang XiaoChangfu Wang
Jan 6, 2016·The Journal of Pharmacy and Pharmacology·Věra KrálováLenka Skálová
Jan 12, 2016·Therapeutic Advances in Medical Oncology·William A HammondKabir Mody

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Citations

Jun 18, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Seyed Ebrahim Alavi, Hasan Ebrahimi Shahmabadi
Aug 8, 2021·British Journal of Pharmacology·Lihua HaoByung-Hyun Park
Oct 1, 2021·Drug Discovery Today·Diana Duarte, Nuno Vale

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Methods Mentioned

BETA
xenografts
xenograft
surgical resection

Clinical Trials Mentioned

NCT03628079
NCT03925662
NCT02687009
NCT02519582
NCT04296851
NCT03950518
NCT03940378

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