Repository of Enriched Structures of Proteins Involved in the Red Blood Cell Environment (RESPIRE)

PloS One
S TéletchéaC Etchebest

Abstract

The Red Blood Cell (RBC) is a metabolically-driven cell vital for processes such a gas transport and homeostasis. RBC possesses at its surface exposing antigens proteins that are critical in blood transfusion. Due to their importance, numerous studies address the cell function as a whole but more and more details of RBC structure and protein content are now studied using massive state-of-the art characterisation techniques. Yet, the resulting information is frequently scattered in many scientific articles, in many databases and specialized web servers. To provide a more compendious view of erythrocytes and of their protein content, we developed a dedicated database called RESPIRE that aims at gathering a comprehensive and coherent ensemble of information and data about proteins in RBC. This cell-driven database lists proteins found in erythrocytes. For a given protein entry, initial data are processed from external portals and enriched by using state-of-the-art bioinformatics methods. As structural information is extremely useful to understand protein function and predict the impact of mutations, a strong effort has been put on the prediction of protein structures with a special treatment for membrane proteins. Browsing the dat...Continue Reading

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Citations

Oct 17, 2019·International Journal of Molecular Sciences·Ennys GheyoucheStéphane Téletchéa
May 18, 2021·Transfusion Medicine Reviews·Aline FlochFrance Pirenne

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Methods Mentioned

BETA
NMR

Software Mentioned

Muscle
PSIPRED
PyMol
JSAV
JSMol
HHblits
Apache
ProDy
Blast
bioperl

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