PMID: 109326Jan 1, 1979

Representation of heavy but not light chain Ig idiotypes on T cell receptors for alloantigens

Experimental Cell Biology
H BinzH Wigzell

Abstract

We have analyzed idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants by the use of different anti-idiotypic antibodies. Such antisera were produced in (Lewis X DA) F1 rats against Lewis anti-DA alloantibodies (= B cell product) and Lewis T lymphocyte receptors with the same specificity. We found that B lymphocytes bear unique idiotypic determinants which are not present on the corresponding T lymphocytes. T cell unique (not shared by B lymphocytes) idiotypes were so far not detected. T cells idiotypic determinants which are present on heavy but not light chains of the corresponding alloantibodies.

Related Concepts

B-Lymphocytes
Polyglobin
Immunoglobulin Idiotypes
Immunoglobulin Heavy Chain Subgroup VH-III
Immunoglobulin Light Chains
Alloantigens
August Rats
T-Lymphocyte

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