Representation of visual landmarks in retrosplenial cortex.

ELife
L. FischerMark Harnett

Abstract

The process by which visual information is incorporated into the brain's spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which head-fixed mice learned the spatial relationship between visual landmark cues and hidden reward locations. Two-photon imaging revealed that these cues served as dominant reference points for most task-active neurons and anchored the spatial code in RSC. This encoding was more robust after task acquisition. Decoupling the virtual environment from mouse behavior degraded spatial representations and provided evidence that supralinear integration of visual and motor inputs contributes to landmark encoding. V1 axons recorded in RSC were less modulated by task engagement but showed surprisingly similar spatial tuning. Our data indicate that landmark representations in RSC are the result of local integration of visual, motor, and spatial information.

Associated Datasets

Feb 5, 2020·Friederike BuckRaul Mojica Soto-Albors

References

Jan 8, 1992·The Journal of Comparative Neurology·T van Groen, J M Wyss
Dec 1, 1987·Brain : a Journal of Neurology·E ValensteinR T Watson
May 10, 1983·The Journal of Comparative Neurology·B A Vogt, M W Miller
Apr 20, 1999·Neuroreport·B G Cooper, S J Mizumori
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·M E LarkumB Sakmann
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
Apr 22, 2004·Hippocampus·Ariane S Etienne, Kathryn J Jeffery
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
Jul 22, 2005·Annual Review of Neuroscience·Michael London, Michael Häusser
Apr 6, 2006·NeuroImage·Hugo J Spiers, Eleanor A Maguire
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark C Fuhs, David S Touretzky
Jun 30, 2006·Neuropsychologia·Eva SvobodaBrian Levine
Jul 22, 2006·Nature Reviews. Neuroscience·Bruce L McNaughtonMay-Britt Moser
Dec 8, 2006·Nature·Ed S LeinAllan R Jones
Dec 19, 2006·Nature Neuroscience·Daoyun Ji, Matthew A Wilson
Mar 8, 2007·Annual Review of Neuroscience·Jeffrey S Taube
Apr 5, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Tadashi InoHidenao Fukuyama
Jun 29, 2007·Hippocampus·Neil BurgessJohn O'Keefe
Sep 5, 2007·The European Journal of Neuroscience·Toshio Miyashita, Kathleen S Rockland
May 6, 2008·Neurobiology of Aging·George PengasPeter J Nestor
Jun 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas VillainGaël Chételat
Sep 2, 2008·Trends in Cognitive Sciences·Russell A Epstein
Jul 1, 1948·Psychological Review·E C TOLMAN
Feb 21, 2009·PLoS Computational Biology·Yoram Burak, Ila R Fiete
Oct 9, 2009·Nature Reviews. Neuroscience·Seralynne D VannEleanor A Maguire
Oct 16, 2009·Nature·Christopher D HarveyDavid W Tank
Mar 2, 2010·Neuron·Cristopher M Niell, Michael P Stryker
Jun 29, 2011·Hippocampus·Natalia L Kononenko, Menno P Witter
Sep 13, 2011·Nature Neuroscience·Sameet Sreenivasan, Ila Fiete
Oct 14, 2011·Frontiers in Computational Neuroscience·Joseph D MonacoKechen Zhang
Aug 23, 2012·PloS One·Stephen D AugerEleanor A Maguire
Sep 18, 2012·Nature Neuroscience·Stephane Valerio, Jeffrey S Taube
May 21, 2013·Nature·Mattia RigottiStefano Fusi
Nov 5, 2013·Nature Neuroscience·Aman B SaleemMatteo Carandini
Nov 10, 2013·Nature·Valerio ManteWilliam T Newsome
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Russell A Epstein, Lindsay K Vass
Feb 13, 2014·PloS One·Zengcai V GuoKarel Svoboda

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Citations

Dec 10, 2020·Brain and Neuroscience Advances·Andrew S AlexanderMichael E Hasselmo
Sep 24, 2021·Neurobiology of Learning and Memory·Eleonora LomiKate J Jeffery

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Methods Mentioned

BETA
confocal microscopy
dissection

Software Mentioned

Mathworks
ViRMeN
Scipy
Matlab

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