Representation of visual scenes by local neuronal populations in layer 2/3 of mouse visual cortex

Frontiers in Neural Circuits
Björn M KampaFritjof Helmchen

Abstract

How are visual scenes encoded in local neural networks of visual cortex? In rodents, visual cortex lacks a columnar organization so that processing of diverse features from a spot in visual space could be performed locally by populations of neighboring neurons. To examine how complex visual scenes are represented by local microcircuits in mouse visual cortex we measured visually evoked responses of layer 2/3 neuronal populations using 3D two-photon calcium imaging. Both natural and artificial movie scenes (10 seconds duration) evoked distributed and sparsely organized responses in local populations of 70-150 neurons within the sampled volumes. About 50% of neurons showed calcium transients during visual scene presentation, of which about half displayed reliable temporal activation patterns. The majority of the reliably responding neurons were activated primarily by one of the four visual scenes applied. Consequently, single-neurons performed poorly in decoding, which visual scene had been presented. In contrast, high levels of decoding performance (>80%) were reached when considering population responses, requiring about 80 randomly picked cells or 20 reliable responders. Furthermore, reliable responding neurons tended to have ...Continue Reading

Citations

Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jae-eun Kang MillerRafael Yuste
Mar 26, 2014·Neuroscience·V BharmauriaS Molotchnikoff
Oct 16, 2015·The European Journal of Neuroscience·V BharmauriaS Molotchnikoff
May 15, 2012·Trends in Neurosciences·Alison L Barth, James F A Poulet
Aug 25, 2015·Frontiers in Neural Circuits·Dylan R MuirBjörn M Kampa
Apr 22, 2015·Annual Review of Neuroscience·Gideon Rothschild, Adi Mizrahi
Feb 5, 2014·Current Opinion in Neurobiology·Matthias Kaschube
Apr 22, 2014·Nature Neuroscience·Emmanouil FroudarakisAndreas S Tolias
Jun 24, 2016·Journal of Neurophysiology·Amanda K KinnischtzkeDaniel J Simons
Nov 14, 2017·Journal of Neural Engineering·Renaud SchuckSimon R Schultz
Dec 15, 2017·PLoS Computational Biology·Dylan R MuirBjörn M Kampa
Dec 14, 2019·Nature Communications·Thomas KnöpfelSamuel J Barnes
Nov 28, 2017·The European Journal of Neuroscience·Sergio Conde-OcazionezKerstin E Schmidt
Aug 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·Deng ZhangMu-Ming Poo
Aug 16, 2016·Science·Luis Carrillo-ReidRafael Yuste
Dec 29, 2020·Journal of Neuroscience Methods·Michael Wenzel, Jordan P Hamm

Methods Mentioned

BETA
electron-microscopy
imaging technique

Related Concepts

Calcium
Laboratory mice
Neurons
Rodent
Visual Cortex
Visual Fields
Proximal
Local
Organizational Groups
Patterns

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