Representation of visual scenes by local neuronal populations in layer 2/3 of mouse visual cortex

Frontiers in Neural Circuits
Björn M KampaFritjof Helmchen


How are visual scenes encoded in local neural networks of visual cortex? In rodents, visual cortex lacks a columnar organization so that processing of diverse features from a spot in visual space could be performed locally by populations of neighboring neurons. To examine how complex visual scenes are represented by local microcircuits in mouse visual cortex we measured visually evoked responses of layer 2/3 neuronal populations using 3D two-photon calcium imaging. Both natural and artificial movie scenes (10 seconds duration) evoked distributed and sparsely organized responses in local populations of 70-150 neurons within the sampled volumes. About 50% of neurons showed calcium transients during visual scene presentation, of which about half displayed reliable temporal activation patterns. The majority of the reliably responding neurons were activated primarily by one of the four visual scenes applied. Consequently, single-neurons performed poorly in decoding, which visual scene had been presented. In contrast, high levels of decoding performance (>80%) were reached when considering population responses, requiring about 80 randomly picked cells or 20 reliable responders. Furthermore, reliable responding neurons tended to have ...Continue Reading


Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jae-eun Kang MillerRafael Yuste
Mar 26, 2014·Neuroscience·V BharmauriaS Molotchnikoff
Oct 16, 2015·The European Journal of Neuroscience·V BharmauriaS Molotchnikoff
May 15, 2012·Trends in Neurosciences·Alison L Barth, James F A Poulet
Aug 25, 2015·Frontiers in Neural Circuits·Dylan R MuirBjörn M Kampa
Apr 22, 2015·Annual Review of Neuroscience·Gideon Rothschild, Adi Mizrahi
Feb 5, 2014·Current Opinion in Neurobiology·Matthias Kaschube
Apr 22, 2014·Nature Neuroscience·Emmanouil FroudarakisAndreas S Tolias
Jun 24, 2016·Journal of Neurophysiology·Amanda K KinnischtzkeDaniel J Simons
Nov 14, 2017·Journal of Neural Engineering·Renaud SchuckSimon R Schultz
Dec 15, 2017·PLoS Computational Biology·Dylan R MuirBjörn M Kampa
Dec 14, 2019·Nature Communications·Thomas KnöpfelSamuel J Barnes
Nov 28, 2017·The European Journal of Neuroscience·Sergio Conde-OcazionezKerstin E Schmidt
Aug 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·Deng ZhangMu-Ming Poo
Aug 16, 2016·Science·Luis Carrillo-ReidRafael Yuste
Dec 29, 2020·Journal of Neuroscience Methods·Michael Wenzel, Jordan P Hamm

Methods Mentioned

imaging technique

Related Concepts

Laboratory mice
Visual Cortex
Visual Fields
Organizational Groups

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.