Representations of Novelty and Familiarity in a Mushroom Body Compartment

Cell
Daisuke HattoriRichard Axel

Abstract

Animals exhibit a behavioral response to novel sensory stimuli about which they have no prior knowledge. We have examined the neural and behavioral correlates of novelty and familiarity in the olfactory system of Drosophila. Novel odors elicit strong activity in output neurons (MBONs) of the α'3 compartment of the mushroom body that is rapidly suppressed upon repeated exposure to the same odor. This transition in neural activity upon familiarization requires odor-evoked activity in the dopaminergic neuron innervating this compartment. Moreover, exposure of a fly to novel odors evokes an alerting response that can also be elicited by optogenetic activation of α'3 MBONs. Silencing these MBONs eliminates the alerting behavior. These data suggest that the α'3 compartment plays a causal role in the behavioral response to novel and familiar stimuli as a consequence of dopamine-mediated plasticity at the Kenyon cell-MBONα'3 synapse.

Citations

Jun 9, 2017·Nature Reviews. Neuroscience·Sian Lewis
Mar 23, 2018·ELife·Pei-Tseng LeeHugo J Bellen
Sep 18, 2018·PLoS Computational Biology·Alex J CopeAndrew B Barron
Oct 17, 2018·The Journal of Experimental Biology·Martyna J GrabowskaBruno van Swinderen
Jan 28, 2020·Journal of Neurogenetics·Yoshinori Aso, Gerald M Rubin
Jan 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Nathaniel C NoyesRonald L Davis
Nov 22, 2019·Nature·Sung Soo KimVivek Jayaraman
Apr 15, 2020·Annual Review of Neuroscience·Mehrab N ModiGlenn C Turner
Jul 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Hiroko AwataYukinori Hirano
Jul 2, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Josephine C AdamsIrving H Zucker
Oct 24, 2018·Perspectives on Behavior Science·Charles I Abramson, Harrington Wells
Mar 4, 2020·ELife·Nicholas James StrausfeldMarcel Ethan Sayre
Feb 15, 2018·Frontiers in Cellular Neuroscience·Sercan SayinIlona C Grunwald Kadow
Dec 5, 2018·Proceedings of the National Academy of Sciences of the United States of America·Sanjoy DasguptaSaket Navlakha
Mar 23, 2019·Learning & Memory·Aliće WeigleinBertram Gerber
Jun 25, 2019·ELife·Xiaoxing ZhangChengyu T Li
Nov 18, 2020·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Meghan M BennettHong Lei
Jan 7, 2021·Cell and Tissue Research·Sofia C BrandãoCarlotta Martelli
Jan 31, 2021·Cell and Tissue Research·K P SijuIlona C Grunwald Kadow
Jan 10, 2021·Neuroscience and Biobehavioral Reviews·Jiří Dvořáček, Dalibor Kodrík
Mar 26, 2021·Scientific Reports·Chang ZhaoWalter Senn
Oct 15, 2020·Neurobiology of Learning and Memory·Andrew R Tapper, Susanna Molas
May 11, 2021·Frontiers in Behavioral Neuroscience·Rebecca R Westwick, Clare C Rittschof
Jun 2, 2021·ELife·Nobuhiro YamagataHiromu Tanimoto
Mar 1, 2021·Journal of Animal Science·William B SmithEric J Scholljegerdes
Jun 20, 2021·Current Biology : CB·Pedro F JacobScott Waddell
Aug 11, 2021·PLoS Computational Biology·Linnie Jiang, Ashok Litwin-Kumar
Oct 1, 2021·Nature·Alice S FrenchGiorgio F Gilestro
Oct 8, 2021·Neuron·Peter Y WangGuangyu Robert Yang
Oct 10, 2021·Scientific Reports·Margaret DriscollDivya Sitaraman

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