Repression of oxidant-induced nuclear factor-kappaB activity mediates placental cytokine responses in gestational diabetes

The Journal of Clinical Endocrinology and Metabolism
M T CoughlanGregory E Rice

Abstract

Although oxidative stress has been implicated in the pathogenesis of type 2 diabetes, limited data are available regarding its role in gestational diabetes mellitus (GDM), a disease of similar pathophysiology. The proinflammatory cytokines TNFalpha, IL-6, and IL-8 are released from the placenta at term and have been implicated in and/or associated with various metabolic events, including decreased insulin sensitivity. Previously we reported differences in the ex situ release of proinflammatory cytokines from placental and adipose tissues obtained from women with and without GDM. We proposed that these differences reflect preexposure and/or adaptation to oxidative stress by GDM tissues. In this study, we tested the hypothesis that placental tissue from women with GDM is less responsive to oxidative stress than tissue from normal women. Under basal conditions, release of TNFalpha, IL-6, and IL-8 was similar in both control and GDM groups. However, 8-isoprostane release was 2-fold greater in the GDM group (P < 0.01). In response to oxidative stress, TNFalpha and 8-isoprostane release and nuclear factor-kappaB (NF-kappaB) DNA-binding activity were significantly increased in normal tissues (20-fold, 2-fold, and 35%, respectively, P ...Continue Reading

Citations

Feb 24, 2007·Cell and Tissue Research·Nicole G RetiGregory E Rice
Jul 22, 2005·Current Diabetes Reports·Xinhua Chen, Theresa O Scholl
Jun 17, 2011·Antioxidants & Redox Signaling·Martha LappasAlicia Jawerbaum
Nov 1, 2011·Antioxidants & Redox Signaling·Rita S Strakovsky, Yuan-Xiang Pan
Oct 1, 2009·Critical Care Medicine·Brian B GrahamIvor S Douglas
Sep 23, 2010·Current Opinion in Pulmonary Medicine·Bilgay Izci-Balserak, Grace W Pien
Jun 8, 2012·International Journal of Endocrinology·Gregory E RiceMurray D Mitchell
Jan 5, 2014·PloS One·Ramkumar MenonRobert N Taylor
May 22, 2013·Journal of Nutrition and Metabolism·Saeid Golbidi, Ismail Laher
Jul 18, 2014·Cell Biology and Toxicology·Ana C Pereira, Fátima Martel
Aug 27, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H MatsufujiT Shibamoto
Jun 21, 2011·Annals of Emergency Medicine·Philipp SchuetzNathan I Shapiro
Apr 6, 2017·Reproductive Biology and Endocrinology : RB&E·Joel Ramírez-EmilianoJessica K Órnelas-Vázquez
Jan 25, 2014·Reproductive Sciences·Ana Paula Machado SpadaTiago Rodrigues
Sep 26, 2017·American Journal of Alzheimer's Disease and Other Dementias·José M de Miguel-YanesAna López-de-Andrés
Mar 5, 2014·American Journal of Reproductive Immunology : AJRI·Ramkumar MenonIstvan Boldogh
Apr 13, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Yangyang ChenYanling He
Nov 7, 2017·Journal of Diabetes Research·Roberto Villalobos-LabraLuis Sobrevia
May 5, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Chiara Di TucciPierluigi Benedetti Panici
Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Emilio Herrera, Henar Ortega-Senovilla

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