Repression of thermotolerance in Dunning R3327 prostate carcinoma cells by 2-deoxy-glucose

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
J RoigasP L Moseley

Abstract

The transient addition of the cytosolic energy depletor 2-deoxy-glucose to cultures of rat prostate carcinoma cells blunted the induction of Hsp70 protein following exposure to elevated temperatures in a manner that appeared to parallel its effects on energy metabolism. While the reduction in stress-induced heat-shock protein expression by treatment with 2-deoxy-glucose had no effects on the acute loss of cellular viability after exposure to heat, the acquisition of thermotolerance in response to a conditioning stimulus was specifically repressed. Therefore, 2-deoxy-glucose will be a useful tool in the investigation of mechanisms that mediate immediate versus chronic responses to cellular stress, including the specific roles played by members of the heat-shock protein family of proteins. These results might have important implications in the design of protocols for the hyperthermic treatment of tumours.

References

Nov 21, 1992·Annals of the New York Academy of Sciences·A Bernelli-ZazzeraL Tacchini
Jan 1, 1988·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·A Yerushalmi
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Feb 26, 1998·Cell·B Bukau, A L Horwich

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Citations

Oct 3, 2006·Cell Stress & Chaperones·Karol DokladnyPope L Moseley
Jul 22, 2020·Plant Disease·Madeline DowlingGuido Schnabel

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